Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics
Endocytosis is a critical step in the process by which many therapeutic nanomedicines reach
their intracellular targets. Our understanding of cellular uptake mechanisms has developed …
their intracellular targets. Our understanding of cellular uptake mechanisms has developed …
Lipid droplet biogenesis and functions in health and disease
Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …
Adipogenesis and metabolic health
AL Ghaben, PE Scherer - Nature reviews Molecular cell biology, 2019 - nature.com
Obesity is characterized by increased adipose tissue mass and has been associated with a
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …
Endocytosis in cancer and cancer therapy
Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …
Mechanisms of endocytosis
GJ Doherty, HT McMahon - Annual review of biochemistry, 2009 - annualreviews.org
Endocytic mechanisms control the lipid and protein composition of the plasma membrane,
thereby regulating how cells interact with their environments. Here, we review what is known …
thereby regulating how cells interact with their environments. Here, we review what is known …
Caveolae as plasma membrane sensors, protectors and organizers
Caveolae are submicroscopic, plasma membrane pits that are abundant in many
mammalian cell types. The past few years have seen a quantum leap in our understanding …
mammalian cell types. The past few years have seen a quantum leap in our understanding …
Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions
I Klaassen, CJF Van Noorden… - Progress in retinal and …, 2013 - Elsevier
Breakdown of the inner endothelial blood-retinal barrier (BRB), as occurs in diabetic
retinopathy, age-related macular degeneration, retinal vein occlusions, uveitis and other …
retinopathy, age-related macular degeneration, retinal vein occlusions, uveitis and other …
[HTML][HTML] Cells respond to mechanical stress by rapid disassembly of caveolae
The functions of caveolae, the characteristic plasma membrane invaginations, remain
debated. Their abundance in cells experiencing mechanical stress led us to investigate their …
debated. Their abundance in cells experiencing mechanical stress led us to investigate their …
Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy
DG Allen, NP Whitehead… - Physiological …, 2016 - journals.physiology.org
Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …
Clathrin-independent pathways of endocytosis
There are many pathways of endocytosis at the cell surface that apparently operate at the
same time. With the advent of new molecular genetic and imaging tools, an understanding of …
same time. With the advent of new molecular genetic and imaging tools, an understanding of …