Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …

Endocytosis is a critical step in the process by which many therapeutic nanomedicines reach
their intracellular targets. Our understanding of cellular uptake mechanisms has developed …

Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …

Obesity is characterized by increased adipose tissue mass and has been associated with a
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …

The plasma membrane of eukaryotic cells is not a simple sheet of lipids and proteins but is
differentiated into subdomains with crucial functions. Caveolae, small pits in the plasma …

Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …

Caveolae are submicroscopic, plasma membrane pits that are abundant in many
mammalian cell types. The past few years have seen a quantum leap in our understanding …

Highlights•Transcytosis is actively suppressed in CNS endothelial cells for barrier
integrity.•Transcytosis is dynamically regulated during development and …

Breakdown of the inner endothelial blood-retinal barrier (BRB), as occurs in diabetic
retinopathy, age-related macular degeneration, retinal vein occlusions, uveitis and other …

Marrow adipose tissue (MAT) accumulates in diverse clinical conditions but remains poorly
understood. Here we show region-specific variation in MAT adipocyte development …