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CuAAC-ensembled 1, 2, 3-triazole-linked isosteres as pharmacophores in drug discovery
The review lays emphasis on the significance of 1, 2, 3-triazoles synthesized via CuAAC
reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory …
reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory …
An overview of 1, 2, 3-triazole-containing hybrids and their potential anticholinesterase activities
Acetylcholine (ACh) neurotransmitter of the cholinergic system in the brain is involved in
learning, memory, stress responses, and cognitive functioning. It is hydrolyzed into choline …
learning, memory, stress responses, and cognitive functioning. It is hydrolyzed into choline …
Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
Triazole derivatives as inhibitors of Alzheimer's disease: current developments and structure-activity relationships
M Xu, Y Peng, L Zhu, S Wang, J Ji… - European journal of …, 2019 - Elsevier
Alzheimer's disease (AD) is a well known neurodegenerative disorder alarming millions of
people worldwide and the subsequent epidemiological statistics highlights the implication of …
people worldwide and the subsequent epidemiological statistics highlights the implication of …
Multitarget therapeutic strategies for Alzheimer's disease: Review on emerging target combinations
Neurodegenerative diseases represent nowadays one of the major health problems.
Despite the efforts made to unveil the mechanism leading to neurodegeneration, it is still not …
Despite the efforts made to unveil the mechanism leading to neurodegeneration, it is still not …
Triazole–peptide conjugate as a modulator of Aβ-aggregation, metal-mediated Aβ-aggregation, and cytotoxicity
Amyloid-β (Aβ) aggregation plays a key role in the pathogenesis of Alzheimer's disease
(AD). Along with this, the presence of redox-active metals like Cu2+ further enhances Aβ …
(AD). Along with this, the presence of redox-active metals like Cu2+ further enhances Aβ …
1, 2, 3‐Triazole rich polymers for flame retardant application: a review
Abstract Development of the non‐halogenated flame retardants (FRs) is an emerging
research area as halogenated FRs are prone to produce carcinogenic and persistent …
research area as halogenated FRs are prone to produce carcinogenic and persistent …
Oxidative modification of proteins: from damage to catalysis, signaling, and beyond
Significance: The systematic investigation of oxidative modification of proteins by reactive
oxygen species started in 1980. Later, it was shown that reactive nitrogen species could also …
oxygen species started in 1980. Later, it was shown that reactive nitrogen species could also …
[HTML][HTML] Synthesis, biological evaluation, and in silico studies of new acetylcholinesterase inhibitors based on quinoxaline scaffold
A quinoxaline scaffold exhibits various bioactivities in pharmacotherapeutic interests. In this
research, twelve quinoxaline derivatives were synthesized and evaluated as new …
research, twelve quinoxaline derivatives were synthesized and evaluated as new …
Hybrid pharmacophore design and synthesis of donepezil-inspired aurone derivative salts as multifunctional acetylcholinesterase inhibitors
R Funahashi, F Matsuura, M Ninomiya, S Okabe… - Bioorganic …, 2024 - Elsevier
Flavonoids, a ubiquitous group of plant polyphenols, are well-known for their beneficial
effects on human health. Their phenylchromane skeletons have structural similarities to …
effects on human health. Their phenylchromane skeletons have structural similarities to …