CuAAC-ensembled 1, 2, 3-triazole-linked isosteres as pharmacophores in drug discovery

A Rani, G Singh, A Singh, U Maqbool, G Kaur… - RSC advances, 2020 - pubs.rsc.org
The review lays emphasis on the significance of 1, 2, 3-triazoles synthesized via CuAAC
reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory …

An overview of 1, 2, 3-triazole-containing hybrids and their potential anticholinesterase activities

SA Khan, MJ Akhtar, U Gogoi, DU Meenakshi, A Das - Pharmaceuticals, 2023 - mdpi.com
Acetylcholine (ACh) neurotransmitter of the cholinergic system in the brain is involved in
learning, memory, stress responses, and cognitive functioning. It is hydrolyzed into choline …

Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease

N Kumar, V Kumar, P Anand, V Kumar… - Bioorganic & Medicinal …, 2022 - Elsevier
Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …

Triazole derivatives as inhibitors of Alzheimer's disease: current developments and structure-activity relationships

M Xu, Y Peng, L Zhu, S Wang, J Ji… - European journal of …, 2019 - Elsevier
Alzheimer's disease (AD) is a well known neurodegenerative disorder alarming millions of
people worldwide and the subsequent epidemiological statistics highlights the implication of …

Multitarget therapeutic strategies for Alzheimer's disease: Review on emerging target combinations

S Maramai, M Benchekroun, MT Gabr… - BioMed Research …, 2020 - Wiley Online Library
Neurodegenerative diseases represent nowadays one of the major health problems.
Despite the efforts made to unveil the mechanism leading to neurodegeneration, it is still not …

Triazole–peptide conjugate as a modulator of Aβ-aggregation, metal-mediated Aβ-aggregation, and cytotoxicity

S Mann, A Kaur, A Kaur, N Priyadarshi… - ACS Chemical …, 2023 - ACS Publications
Amyloid-β (Aβ) aggregation plays a key role in the pathogenesis of Alzheimer's disease
(AD). Along with this, the presence of redox-active metals like Cu2+ further enhances Aβ …

1, 2, 3‐Triazole rich polymers for flame retardant application: a review

K Sykam, S Donempudi, P Basak - Journal of Applied Polymer …, 2022 - Wiley Online Library
Abstract Development of the non‐halogenated flame retardants (FRs) is an emerging
research area as halogenated FRs are prone to produce carcinogenic and persistent …

Oxidative modification of proteins: from damage to catalysis, signaling, and beyond

M Demasi, O Augusto, EJH Bechara… - Antioxidants & redox …, 2021 - liebertpub.com
Significance: The systematic investigation of oxidative modification of proteins by reactive
oxygen species started in 1980. Later, it was shown that reactive nitrogen species could also …

[HTML][HTML] Synthesis, biological evaluation, and in silico studies of new acetylcholinesterase inhibitors based on quinoxaline scaffold

P Suwanhom, J Saetang, P Khongkow, T Nualnoi… - Molecules, 2021 - mdpi.com
A quinoxaline scaffold exhibits various bioactivities in pharmacotherapeutic interests. In this
research, twelve quinoxaline derivatives were synthesized and evaluated as new …

Hybrid pharmacophore design and synthesis of donepezil-inspired aurone derivative salts as multifunctional acetylcholinesterase inhibitors

R Funahashi, F Matsuura, M Ninomiya, S Okabe… - Bioorganic …, 2024 - Elsevier
Flavonoids, a ubiquitous group of plant polyphenols, are well-known for their beneficial
effects on human health. Their phenylchromane skeletons have structural similarities to …