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[HTML][HTML] Development of Next Generation Streptococcus pneumoniae Vaccines Conferring Broad Protection
Streptococcus pneumoniae is a major pathogen causing pneumonia with over 2 million
deaths annually, especially in young children and the elderly. To date, at least 98 different …
deaths annually, especially in young children and the elderly. To date, at least 98 different …
Emerging vaccine strategies against the incessant pneumococcal disease
The incidence of invasive pneumococcal disease (IPD) caused by infection with the
pathogen Streptococcus pneumoniae (Spn) has been on a downward trend for decades due …
pathogen Streptococcus pneumoniae (Spn) has been on a downward trend for decades due …
Recent progress in pneumococcal protein vaccines
S Li, H Liang, SH Zhao, XY Yang, Z Guo - Frontiers in Immunology, 2023 - frontiersin.org
Pneumococcal infections continue to pose a significant global health concern, necessitating
the development of effective vaccines. Despite the progress shown by pneumococcal …
the development of effective vaccines. Despite the progress shown by pneumococcal …
Pneumococcal surface proteins as virulence factors, immunogens, and conserved vaccine targets
Streptococcus pneumoniae is an opportunistic pathogen that causes over 1 million deaths
annually despite the availability of several multivalent pneumococcal conjugate vaccines …
annually despite the availability of several multivalent pneumococcal conjugate vaccines …
An in vivo atlas of host–pathogen transcriptomes during Streptococcus pneumoniae colonization and disease
Streptococcus pneumoniae (Spn) colonizes the nasopharynx and can cause pneumonia.
From the lungs it spreads to the bloodstream and causes organ damage. We characterized …
From the lungs it spreads to the bloodstream and causes organ damage. We characterized …
Immunoinformatics-aided design of a new multi-epitope vaccine adjuvanted with domain 4 of pneumolysin against Streptococcus pneumoniae strains
Abstract Background Streptococcus pneumoniae (Pneumococcus) has remained a leading
cause of fatal infections such as pneumonia, meningitis, and sepsis. Moreover, this …
cause of fatal infections such as pneumonia, meningitis, and sepsis. Moreover, this …
A nanogel-based trivalent PspA nasal vaccine protects macaques from intratracheal challenge with pneumococci
R Nakahashi-Ouchida, Y Uchida, Y Yuki, Y Katakai… - Vaccine, 2021 - Elsevier
Current polysaccharide-based pneumococcal vaccines are effective but not compatible with
all serotypes of Streptococcus pneumoniae. We previously developed an adjuvant-free …
all serotypes of Streptococcus pneumoniae. We previously developed an adjuvant-free …
Menstrual hygiene management practices and associated health outcomes among school-going adolescents in rural Gambia
HM Nabwera, V Shah, R Neville, F Sosseh… - PloS one, 2021 - journals.plos.org
Inadequate menstrual hygiene management (MHM) practices have been associated with
adverse health outcomes. This study aimed to describe MHM practices among schoolgirls …
adverse health outcomes. This study aimed to describe MHM practices among schoolgirls …
A Jack of All Trades: The Role of Pneumococcal Surface Protein A in the Pathogenesis of Streptococcus pneumoniae
Streptococcus pneumoniae (Spn), or the pneumococcus, is a Gram-positive bacterium that
colonizes the upper airway. Spn is an opportunistic pathogen capable of life-threatening …
colonizes the upper airway. Spn is an opportunistic pathogen capable of life-threatening …
Characterization and specification of a trivalent protein-based pneumococcal vaccine formulation using an adjuvant-free nanogel nasal delivery system
Y Yuki, Y Uchida, S Sawada… - Molecular …, 2021 - ACS Publications
We previously developed a safe and effective nasal vaccine delivery system using a self-
assembled nanosized hydrogel (nanogel) made from a cationic cholesteryl pullulan. Here …
assembled nanosized hydrogel (nanogel) made from a cationic cholesteryl pullulan. Here …