[HTML][HTML] Development of Next Generation Streptococcus pneumoniae Vaccines Conferring Broad Protection

M Masomian, Z Ahmad, L Ti Gew, CL Poh - Vaccines, 2020 - mdpi.com
Streptococcus pneumoniae is a major pathogen causing pneumonia with over 2 million
deaths annually, especially in young children and the elderly. To date, at least 98 different …

Emerging vaccine strategies against the incessant pneumococcal disease

JA Duke, FY Avci - npj Vaccines, 2023 - nature.com
The incidence of invasive pneumococcal disease (IPD) caused by infection with the
pathogen Streptococcus pneumoniae (Spn) has been on a downward trend for decades due …

Recent progress in pneumococcal protein vaccines

S Li, H Liang, SH Zhao, XY Yang, Z Guo - Frontiers in Immunology, 2023 - frontiersin.org
Pneumococcal infections continue to pose a significant global health concern, necessitating
the development of effective vaccines. Despite the progress shown by pneumococcal …

Pneumococcal surface proteins as virulence factors, immunogens, and conserved vaccine targets

J Aceil, FY Avci - Frontiers in cellular and infection microbiology, 2022 - frontiersin.org
Streptococcus pneumoniae is an opportunistic pathogen that causes over 1 million deaths
annually despite the availability of several multivalent pneumococcal conjugate vaccines …

An in vivo atlas of host–pathogen transcriptomes during Streptococcus pneumoniae colonization and disease

A D'Mello, AN Riegler, E Martínez, SM Beno… - Proceedings of the …, 2020 - pnas.org
Streptococcus pneumoniae (Spn) colonizes the nasopharynx and can cause pneumonia.
From the lungs it spreads to the bloodstream and causes organ damage. We characterized …

Immunoinformatics-aided design of a new multi-epitope vaccine adjuvanted with domain 4 of pneumolysin against Streptococcus pneumoniae strains

M Shafaghi, Z Bahadori, H Madanchi, MM Ranjbar… - BMC …, 2023 - Springer
Abstract Background Streptococcus pneumoniae (Pneumococcus) has remained a leading
cause of fatal infections such as pneumonia, meningitis, and sepsis. Moreover, this …

A nanogel-based trivalent PspA nasal vaccine protects macaques from intratracheal challenge with pneumococci

R Nakahashi-Ouchida, Y Uchida, Y Yuki, Y Katakai… - Vaccine, 2021 - Elsevier
Current polysaccharide-based pneumococcal vaccines are effective but not compatible with
all serotypes of Streptococcus pneumoniae. We previously developed an adjuvant-free …

Menstrual hygiene management practices and associated health outcomes among school-going adolescents in rural Gambia

HM Nabwera, V Shah, R Neville, F Sosseh… - PloS one, 2021 - journals.plos.org
Inadequate menstrual hygiene management (MHM) practices have been associated with
adverse health outcomes. This study aimed to describe MHM practices among schoolgirls …

A Jack of All Trades: The Role of Pneumococcal Surface Protein A in the Pathogenesis of Streptococcus pneumoniae

JR Lane, M Tata, DE Briles, CJ Orihuela - Frontiers in Cellular and …, 2022 - frontiersin.org
Streptococcus pneumoniae (Spn), or the pneumococcus, is a Gram-positive bacterium that
colonizes the upper airway. Spn is an opportunistic pathogen capable of life-threatening …

Characterization and specification of a trivalent protein-based pneumococcal vaccine formulation using an adjuvant-free nanogel nasal delivery system

Y Yuki, Y Uchida, S Sawada… - Molecular …, 2021 - ACS Publications
We previously developed a safe and effective nasal vaccine delivery system using a self-
assembled nanosized hydrogel (nanogel) made from a cationic cholesteryl pullulan. Here …