Persistent infection with high-risk human papillomaviruses (HR-HPVs) is the causal factor in
over 99% of cervical cancer cases, and a significant proportion of oropharyngeal and …

Human papillomaviruses (HPVs) have evolved over millions of years to propagate
themselves in a range of different animal species including humans. Viruses that have co …

Human papillomaviruses (HPVs) comprise a diverse group, and have different epithelial
tropisms and life-cycle strategies. Many HPVs are classified as low-risk, as they are only …

Infection with HPV starts with the access of the viral particles to basal cells in the epidermis,
potentially via microtraumas to the skin. The basal cells are able to keep away these …

The E5 proteins are short transmembrane proteins encoded by many animal and human
papillomaviruses. These proteins display transforming activity in cultured cells and animals …

The combination of irradiated fibroblast feeder cells and Rho kinase inhibitor, Y-27632,
conditionally induces an indefinite proliferative state in primary mammalian epithelial cells …

Antibody–drug conjugate (ADC) and immune checkpoint blockade (ICB) offer promising
approaches for cancer treatment. Here, we describe an ADC constructed by conjugating anti …

The oncogenic potential of papillomaviruses (PVs) has been appreciated since the 1930s
yet the mechanisms of virally-mediated cellular transformation are still being revealed …

The channel-forming activity of a family of small, hydrophobic integral membrane proteins
termed 'viroporins' is essential to the life cycles of an increasingly diverse range of RNA and …

The tumor suppressor LKB1 is a serine/threonine protein kinase that is frequently mutated in
human lung adenocarcinoma (LUAD). LKB1 regulates a complex signaling network that is …