Cardiac development and function are becoming increasingly well understood from different
angles, including signalling, transcriptional and epigenetic mechanisms. By contrast, the …

Background Alternative splicing of pre‐mRNA is a fundamental regulatory process in
multicellular eukaryotes, significantly contributing to the diversification of the human …

Hypoplastic left heart syndrome (HLHS) is characterized by underdevelopment of left sided
structures including the ventricle, valves, and aorta. Prevailing paradigm suggests that …

Insulin secretion is a tightly regulated process that is vital for maintaining blood glucose
homeostasis. Although the molecular components of insulin granule trafficking and secretion …

Cleavage and polyadenylation of pre-mRNAs is a necessary step for gene expression and
function. Majority of human genes exhibit multiple polyadenylation sites, which can be …

Abstract Background and Objective Oral squamous cell carcinoma (OSCC) is a significant
global health concern due to its aggressive nature and poor prognosis. Recent research has …

Purpose Gliomas and their surrounding microenvironment constantly interact to promote
tumorigenicity, yet the underlying posttranscriptional regulatory mechanisms that govern this …

Regulation of mRNA polyadenylation is important for response to external signals and
differentiation in several cell types, and results in mRNA isoforms that vary in the amount of …

Vascular complications are the main cause of diabetes mellitus-associated morbidity and
mortality. Oxidative stress and metabolic dysfunction underly injury to the vascular …

Alternative splicing (AS) is a fundamental mechanism contributing to proteome diversity, yet
its comprehensive landscape and regulatory dynamics during skeletal muscle development …