A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy

CK Stein-Thoeringer, NY Saini, E Zamir… - Nature medicine, 2023 - nature.com
Increasing evidence suggests that the gut microbiome may modulate the efficacy of cancer
immunotherapy. In a B cell lymphoma patient cohort from five centers in Germany and the …

Antibiotics: from mechanism of action to resistance and beyond

S Saikia, P Chetia - Indian Journal of Microbiology, 2024 - Springer
Antibiotics are the super drugs that have revolutionized modern medicine by curing many
infectious diseases caused by various microbes. They efficiently inhibit the growth and …

[HTML][HTML] Biofilm Production in Intensive Care Units: Challenges and Implications

F Taner, B Baddal, L Theodoridis, S Petrovski - Pathogens, 2024 - mdpi.com
The prevalence of infections amongst intensive care unit (ICU) patients is inevitably high,
and the ICU is considered the epicenter for the spread of multidrug-resistant bacteria …

Short-and long-term effects of different antibiotics on the gut microbiota and cytokines level in mice

J Wang, Q **ang, S Gu, Y Gu, M Yao… - Infection and Drug …, 2022 - Taylor & Francis
Background Antibiotics are the first line of treatment for infectious diseases. However, their
overuse can increase the spread of drug-resistant bacteria. The present study analyzed the …

Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice

MK Joo, YJ Shin, DH Kim - Scientific Reports, 2023 - nature.com
Antibiotics are increasingly recognized as causing neuropsychiatric side effects including
depression and anxiety. Alterations in central serotonin and 5-HT receptor expression are …

Vagus nerve-dependent effects of fluoxetine on anxiety-and depression-like behaviors in mice

MK Joo, DH Kim - European journal of pharmacology, 2023 - Elsevier
The vagus nerve is a major pathway in the body that is responsible for regulating the activity
of the parasympathetic nervous system, which plays an important role in mood disorders …

Moderate and transient impact of antibiotic use on the gut microbiota in a rural Vietnamese cohort

VTN Bich, NG Le, D Barnett, J Chan, N van Best… - Scientific Reports, 2022 - nature.com
The human gut microbiota has been shown to be significantly perturbed by antibiotic use,
while recovering to the pre-treatment state several weeks after short antibiotic exposure. The …

Early reduction in gut microbiota diversity in critically ill patients is associated with mortality

H Wozniak, N Gaïa, V Lazarevic, C Le Terrier… - Annals of Intensive …, 2024 - Springer
Critical illness is associated with an altered gut microbiota, yet its association with poor
outcomes remains unclear. This study evaluates the early gut microbiota diversity changes …

[PDF][PDF] Factor associated with in-hospital mortality among infective endocarditis patients

HH Chua, AYY Fong - J. Malays, 2023 - e-mjm.org
Introduction: Despite recent advancements in the diagnosis and management of infective
endocarditis (IE), it is associated with substantial morbidity and mortality. Our study objective …

Recent Insights into the Evolving Role of the Gut Microbiome in Critical Care

S Lee, PE Wischmeyer, CD Mintz… - Critical Care …, 2024 - criticalcare.theclinics.com
Over the past decade, there has been an exponential increase in our understanding of
crucial roles played by the human microbiota (ie, complex community of bacteria, fungi, and …