miRNAs as potential game-changers in bone diseases: Future medicinal and clinical uses

AS Doghish, MS Elballal, O Elazazy… - … -Research and Practice, 2023 - Elsevier
Abstract MicroRNAs (miRNAs), short, highly conserved non-coding RNA, influence gene
expression by sequential mechanisms such as mRNA breakdown or translational …

The role of miR‐29 family in disease

M Horita, C Farquharson… - Journal of cellular …, 2021 - Wiley Online Library
MicroRNAs are small noncoding RNAs that can bind to the target sites in the 3'‐untranslated
region of messenger RNA to regulate posttranscriptional gene expression. Increasing …

Exosomal hsa_circ_0006859 is a potential biomarker for postmenopausal osteoporosis and enhances adipogenic versus osteogenic differentiation in human bone …

F Zhi, Y Ding, R Wang, Y Yang, K Luo… - Stem Cell Research & …, 2021 - Springer
Background As one of the most common chronic diseases in the world, osteoporosis occurs
especially in postmenopausal women. Circular RNAs (circRNAs) are emerging as major …

Emerging role of extracellular vesicles in bone remodeling

M Liu, Y Sun, Q Zhang - Journal of Dental Research, 2018 - journals.sagepub.com
Extracellular vesicles (EVs), as nanometer-scale particles, include exosomes, microvesicles,
and apoptotic bodies. EVs are released by most cell types, such as bone marrow stem cells …

[HTML][HTML] The role of micro RNA and long-non-coding RNA in osteoporosis

NY Ko, LR Chen, KH Chen - International Journal of Molecular Sciences, 2020 - mdpi.com
Osteoporosis is a major concern worldwide and can be attributed to an imbalance between
osteoblastic bone formation and osteoclastic bone resorption due to the natural aging …

Deregulated miRNAs in bone health: Epigenetic roles in osteoporosis

D Bellavia, A De Luca, V Carina, V Costa, L Raimondi… - Bone, 2019 - Elsevier
MicroRNA (miRNA) has shown to enhance or inhibit cell proliferation, differentiation and
activity of different cell types in bone tissue. The discovery of miRNA actions and their targets …

Circulating microRNAs as potential diagnostic biomarkers for osteoporosis

AY Mandourah, L Ranganath, R Barraclough… - Scientific reports, 2018 - nature.com
Osteoporosis is the most common age-related bone disease worldwide and is usually
clinically asymptomatic until the first fracture happens. MicroRNAs are critical molecular …

The osteoporosis/microbiota linkage: the role of miRNA

M De Martinis, L Ginaldi, A Allegra, MM Sirufo… - International Journal of …, 2020 - mdpi.com
Hundreds of trillions of bacteria are present in the human body in a mutually beneficial
symbiotic relationship with the host. A stable dynamic equilibrium exists in healthy …

New insights into the epigenetics of osteoporosis

JG Letarouilly, O Broux, A Clabaut - Genomics, 2019 - Elsevier
Osteoporosis is characterized by reduced bone formation and accumulation of adipocytes in
the bone marrow compartment. The decrease in bone mass results from an imbalance …

Serum microRNAs as novel biomarkers for osteoporotic vertebral fractures

P Zarecki, M Hackl, J Grillari, M Debono, R Eastell - Bone, 2020 - Elsevier
Context Vertebral fractures are the hallmark of osteoporosis. MicroRNAs (miRNAs) are a
prominent class of gene regulators likely to affect bone homeostasis, including bone …