Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation

JAHR Claassen, DHJ Thijssen… - Physiological …, 2021 - journals.physiology.org
Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Acid–base balance and cerebrovascular regulation

HG Caldwell, JMJR Carr, JS Minhas… - The Journal of …, 2021 - Wiley Online Library
The regulation and defence of intracellular pH is essential for homeostasis. Indeed,
alterations in cerebrovascular acid–base balance directly affect cerebral blood flow (CBF) …

Carbon dioxide and MAPK signalling: towards therapy for inflammation

H Gałgańska, W Jarmuszkiewicz… - Cell Communication and …, 2023 - Springer
Inflammation, although necessary to fight infections, becomes a threat when it exceeds the
capability of the immune system to control it. In addition, inflammation is a cause and/or …

Arterial carbon dioxide and bicarbonate rather than pH regulate cerebral blood flow in the setting of acute experimental metabolic alkalosis

HG Caldwell, CA Howe, CJ Chalifoux… - The Journal of …, 2021 - Wiley Online Library
Key points We investigated the influence of arterial () with and without acutely elevated
arterial pH and bicarbonate ([HCO3–]) on cerebral blood flow (CBF) regulation in the …

Dynamic cerebral autoregulation post endovascular thrombectomy in acute ischemic stroke

F Sheriff, P Castro, M Kozberg, S LaRose, A Monk… - Brain sciences, 2020 - mdpi.com
The development of the endovascular thrombectomy (EVT) technique has revolutionized
acute stroke management for patients with large vessel occlusions (LVOs). The impact of …

General anesthesia but not conscious sedation improves functional outcome in patients receiving endovascular thrombectomy for acute ischemic stroke: a meta …

CW Lee, YP Chang, YT Huang, CH Hsing… - Frontiers in …, 2022 - frontiersin.org
Background This study aimed at comparing the difference in prognostic outcomes between
patients receiving general anesthesia (GA) and conscious sedation (CS) for endovascular …

Admission neutrophil–lymphocyte ratio predicts rebleeding following aneurismal subarachnoid hemorrhage

JY Wang, XT Zhang, JQ Wang, CY Wang, WL Zheng… - World neurosurgery, 2020 - Elsevier
Objective The relationship between neutrophil–lymphocyte ratio (NLR) and the occurrence
of rebleeding in aneurysmal subarachnoid hemorrhage (aSAH) is poorly understood. Our …

A brief history of the development of transcranial tissue doppler ultrasound

JK Nicholls, A Lecchini-Visintini, J Ince… - Interface …, 2024 - royalsocietypublishing.org
This article documents the early development of the first transcranial Doppler (TCD)-based
ultrasound system for continuous monitoring of brain tissue pulsations (BTPs). Transcranial …

The effects of arterial CO2 on the injured brain: two faces of the same coin

DA Godoy, M Rovegno, C Lazaridis, R Badenes - Journal of Critical Care, 2021 - Elsevier
Serum levels of carbon dioxide (CO 2) closely regulate cerebral blood flow (CBF) and
actively participate in different aspects of brain physiology such as hemodynamics …

Hypocapnia, ischemic lesions, and outcomes after intracerebral hemorrhage

S Hextrum, JS Minhas, EM Liotta, FA Sorond… - Journal of the …, 2020 - Elsevier
Background An association between spontaneous hyperventilation, delayed cerebral
ischemia, and poor clinical outcomes has been reported in subarachnoid hemorrhage. We …