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Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …
Acid–base balance and cerebrovascular regulation
The regulation and defence of intracellular pH is essential for homeostasis. Indeed,
alterations in cerebrovascular acid–base balance directly affect cerebral blood flow (CBF) …
alterations in cerebrovascular acid–base balance directly affect cerebral blood flow (CBF) …
Carbon dioxide and MAPK signalling: towards therapy for inflammation
H Gałgańska, W Jarmuszkiewicz… - Cell Communication and …, 2023 - Springer
Inflammation, although necessary to fight infections, becomes a threat when it exceeds the
capability of the immune system to control it. In addition, inflammation is a cause and/or …
capability of the immune system to control it. In addition, inflammation is a cause and/or …
Arterial carbon dioxide and bicarbonate rather than pH regulate cerebral blood flow in the setting of acute experimental metabolic alkalosis
HG Caldwell, CA Howe, CJ Chalifoux… - The Journal of …, 2021 - Wiley Online Library
Key points We investigated the influence of arterial () with and without acutely elevated
arterial pH and bicarbonate ([HCO3–]) on cerebral blood flow (CBF) regulation in the …
arterial pH and bicarbonate ([HCO3–]) on cerebral blood flow (CBF) regulation in the …
Dynamic cerebral autoregulation post endovascular thrombectomy in acute ischemic stroke
The development of the endovascular thrombectomy (EVT) technique has revolutionized
acute stroke management for patients with large vessel occlusions (LVOs). The impact of …
acute stroke management for patients with large vessel occlusions (LVOs). The impact of …
General anesthesia but not conscious sedation improves functional outcome in patients receiving endovascular thrombectomy for acute ischemic stroke: a meta …
Background This study aimed at comparing the difference in prognostic outcomes between
patients receiving general anesthesia (GA) and conscious sedation (CS) for endovascular …
patients receiving general anesthesia (GA) and conscious sedation (CS) for endovascular …
Admission neutrophil–lymphocyte ratio predicts rebleeding following aneurismal subarachnoid hemorrhage
JY Wang, XT Zhang, JQ Wang, CY Wang, WL Zheng… - World neurosurgery, 2020 - Elsevier
Objective The relationship between neutrophil–lymphocyte ratio (NLR) and the occurrence
of rebleeding in aneurysmal subarachnoid hemorrhage (aSAH) is poorly understood. Our …
of rebleeding in aneurysmal subarachnoid hemorrhage (aSAH) is poorly understood. Our …
A brief history of the development of transcranial tissue doppler ultrasound
JK Nicholls, A Lecchini-Visintini, J Ince… - Interface …, 2024 - royalsocietypublishing.org
This article documents the early development of the first transcranial Doppler (TCD)-based
ultrasound system for continuous monitoring of brain tissue pulsations (BTPs). Transcranial …
ultrasound system for continuous monitoring of brain tissue pulsations (BTPs). Transcranial …
The effects of arterial CO2 on the injured brain: two faces of the same coin
Serum levels of carbon dioxide (CO 2) closely regulate cerebral blood flow (CBF) and
actively participate in different aspects of brain physiology such as hemodynamics …
actively participate in different aspects of brain physiology such as hemodynamics …
Hypocapnia, ischemic lesions, and outcomes after intracerebral hemorrhage
S Hextrum, JS Minhas, EM Liotta, FA Sorond… - Journal of the …, 2020 - Elsevier
Background An association between spontaneous hyperventilation, delayed cerebral
ischemia, and poor clinical outcomes has been reported in subarachnoid hemorrhage. We …
ischemia, and poor clinical outcomes has been reported in subarachnoid hemorrhage. We …