Endothelial-to-mesenchymal transition is a dynamic process in which endothelial cells
suppress constituent endothelial properties and take on mesenchymal cell behaviors. To …

Heart disease is the leading cause of death worldwide. Despite decades of research, most
heart pathologies have limited treatments, and often the only curative approach is heart …

The valves of the heart are crucial for ensuring that blood flows in one direction from the
heart, through the lungs and back to the rest of the body. Heart valve development is …

In recent years, the explosive growth of spatial technologies has enabled the
characterization of spatial heterogeneity of tissue architectures. Compared to traditional …

Damage-induced fibrotic scarring limits tissue regeneration in mammals and is a leading
cause of morbidity. In contrast, species like zebrafish can regenerate damaged tissues …

Cardiac injury leads to the loss of cardiomyocytes, which are rapidly replaced by the
proliferation of the surviving cells in zebrafish, but not in mammals. In both the regenerative …

In heart disease patients, myocyte loss or malfunction invariably leads to fibrosis, involving
the activation and accumulation of cardiac fibroblasts that deposit large amounts of …

The cardiac developmental network has been associated with myocardial regenerative
potential. However, the embryonic signals triggered following injury have yet to be fully …

Rationale: The transcription factor NFATC1 (nuclear factor of activated T-cell 1) has been
implicated in cardiac valve formation in humans and mice, but we know little about the …

Many extensible tissues such as skin, lungs, and blood vessels require elasticity to function
properly. The recoil of elastic energy stored during a stretching phase is provided by elastic …