CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled …

SARS-CoV-2 infection is benign in most individuals but, in around 10% of cases, it triggers
hypoxaemic COVID-19 pneumonia, which leads to critical illness in around 3% of cases …

T cell exhaustion limits antitumor immunity, but the molecular determinants of this process
remain poorly understood. Using a chronic stimulation assay, we performed genome-wide …

Long COVID, the prolonged illness and fatigue suffered by a small proportion of those
infected with SARS‐CoV‐2, is placing an increasing burden on individuals and society. A …

Abstract The coronavirus disease 2019 (COVID-19) pandemic has claimed millions of lives
and caused a global economic crisis. No effective antiviral drugs are currently available to …

RNA molecules start assembling into ribonucleoprotein (RNP) complexes during
transcription. Dynamic RNP assembly, largely directed by cis-acting elements on the RNA …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of
symptoms in infected individuals, from mild respiratory illness to acute respiratory distress …

The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …

SARS-CoV-2 carries the largest single-stranded RNA genome and is the causal pathogen of
the ongoing COVID-19 pandemic. How the SARS-CoV-2 RNA genome is folded in the virion …

The ability of a virus to spread between individuals, its replication capacity and the clinical
course of the infection are macroscopic consequences of a multifaceted molecular …