Leishmaniasis is a disease that affects 2 million people and kills 70000 persons every year.
It is caused by Leishmania species, which are human protozoan parasites of the …

In Kinetoplastida, trypanothione and trypanothione reductase (TRYR) provide an
intracellular reducing environment, substituting for the glutathione–glutathione reductase …

Cation-π bonds and amino-aromatic interactions are known to be important contributors to
protein architecture and stability, and their role in ligand-protein interactions has also been …

Open-access drug discovery provides a substantial resource for diseases primarily affecting
the poor and disadvantaged. The open-access Pathogen Box collection is comprised of …

Background: Trypanothione reductase (TR) helps to maintain an intracellular reducing
environment in trypanosomatids, a group of protozoan parasites that afflict humans and …

Viewed globally, parasitic diseases such as malaria and Chagas' cardiopathy pose an
increasing threat to human health and welfare. Recognition of this problem and the …

A prediction algorithm of the binding affinity of ligands to trypanothione reductase (TR), the
enzyme replacing glutathione reductase in the metabolism of trypanosomatidae, has been …

The presence of thiols in living systems is critical for the maintenance of cellular redox
potentials and protein thiol-disulfide ratios, as well as for the protection of cells from reactive …