Perforin and granzymes: function, dysfunction and human pathology
A defining property of cytotoxic lymphocytes is their expression and regulated secretion of
potent toxins, including the pore-forming protein perforin and serine protease granzymes …
potent toxins, including the pore-forming protein perforin and serine protease granzymes …
Knocking'em dead: pore-forming proteins in immune defense
X Liu, J Lieberman - Annual review of immunology, 2020 - annualreviews.org
Immune cells use a variety of membrane-disrupting proteins [complement, perforin, perforin-
2, granulysin, gasdermins, mixed lineage kinase domain–like pseudokinase (MLKL)] to …
2, granulysin, gasdermins, mixed lineage kinase domain–like pseudokinase (MLKL)] to …
[HTML][HTML] Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells
ME Pipkin, JA Sacks, F Cruz-Guilloty, MG Lichtenheld… - Immunity, 2010 - cell.com
Summary Interleukin (IL)-2 and inflammation regulate effector and memory cytolytic T-
lymphocyte (CTL) generation during infection. We demonstrate a complex interplay between …
lymphocyte (CTL) generation during infection. We demonstrate a complex interplay between …
Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs
F Cruz-Guilloty, ME Pipkin, IM Djuretic… - Journal of Experimental …, 2009 - rupress.org
Activation of naive CD8+ T cells with antigen induces their differentiation into effector
cytolytic T lymphocytes (CTLs). CTLs lyse infected or aberrant target cells by exocytosis of …
cytolytic T lymphocytes (CTLs). CTLs lyse infected or aberrant target cells by exocytosis of …
[HTML][HTML] The transcription factor Runx3 establishes chromatin accessibility of cis-regulatory landscapes that drive memory cytotoxic T lymphocyte formation
T cell receptor (TCR) stimulation of naive CD8+ T cells initiates reprogramming of cis-
regulatory landscapes that specify effector and memory cytotoxic T lymphocyte (CTL) …
regulatory landscapes that specify effector and memory cytotoxic T lymphocyte (CTL) …
Delivering the kiss of death: progress on understanding how perforin works
Killer lymphocytes release perforin and granzymes from cytotoxic granules into the
immunological synapse to destroy target cells as a critical mechanism in the defense against …
immunological synapse to destroy target cells as a critical mechanism in the defense against …
Cytotoxic CD4 T cells in antiviral immunity
CD4 T cells that acquire cytotoxic phenotype and function have been repeatedly identified in
humans, mice, and other species in response to many diverse pathogens. Since CD4 …
humans, mice, and other species in response to many diverse pathogens. Since CD4 …
Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis
SJ Vastert, R Van Wijk, LE D'Urbano… - …, 2010 - academic.oup.com
Objective. Macrophage activation syndrome (MAS) in systemic onset juvenile idiopathic
arthritis (SoJIA) is considered to be an acquired form of familial haemophagocytic …
arthritis (SoJIA) is considered to be an acquired form of familial haemophagocytic …
The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells
L Wang, KF Wildt, E Castro, Y **ong, L Feigenbaum… - Immunity, 2008 - cell.com
How CD4-CD8 differentiation is maintained in mature T cells is largely unknown. The
present study has examined the role in this process of the zinc finger protein Zbtb7b, a …
present study has examined the role in this process of the zinc finger protein Zbtb7b, a …
Oxidative stress and alopecia areata
Y Ma, Z Sun, YM Li, H Xu - Frontiers in Medicine, 2023 - frontiersin.org
Alopecia areata (AA) is an inflammatory autoimmune disease characterized by non-scarring
hair loss on the scalp or any other part of the hair-bearing skin. While the collapse of the …
hair loss on the scalp or any other part of the hair-bearing skin. While the collapse of the …