Retinoic acid (RA) signalling has a central role during vertebrate development. RA
synthesized in specific locations regulates transcription by interacting with nuclear RA …

Organization and Evolution of Hox/HOM-C Complexes The genomic structural and
organizational similarities between vertebrate Hox and Drosophila HOM-C complexes …

Retinoids (ie, vitamin A, all-trans retinoic acid, and related signaling molecules) induce the
differentiation of various types of stem cells. Nuclear retinoic acid receptors mediate most but …

HOX genes encode an evolutionarily conserved set of transcription factors that control how
the phenotype of an organism becomes organized during development based on its genetic …

A number of studies have suggested that the active derivative of vitamin A, retinoic acid
(RA), may be important for early development of mammalian embryos 1, 2. Severe vitamin A …

Vitamin A (retinol) is a critical micronutrient required for the control of stem cell functions, cell
differentiation, and cell metabolism in many different cell types, both during embryogenesis …

The key role of vitamin A in embryonal development is reviewed. Special emphasis is given
to the physiological action of retinoids, as evident from the retinoid ligand knockout models …

IN THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …

Retinoids are ubiquitous signaling molecules that influence nearly every cell type, exert
profound effects on development, and complement cancer chemotherapeutic regimens. All …

Numerous congenital malformations have been observed in fetuses of vitamin A-deficient
(VAD) dams [Wilson, JG, Roth, CB, Warkany, J.,(1953), Am. J. Anat. 92, 189-217]. Previous …