Every day thousands of surgical procedures are performed to replace or repair tissue that
has been damaged through disease or trauma. The develo** field of tissue engineering …

The stiffness and nanotopographical characteristics of the extracellular matrix (ECM)
influence numerous developmental, physiological, and pathological processes in vivo …

Abstract Development of natural protein-based fibrous scaffolds with tunable physical
properties and biocompatibility is highly desirable to construct three-dimensional (3D), fully …

The modulus of elasticity of the extracellular matrix (ECM), often referred to in a biological
context as “stiffness,” naturally varies within the body, eg, hard bones and soft tissue …

The mechanical properties of the extracellular matrix have recently been shown to promote
myofibroblast differentiation and lung fibrosis. Mechanisms by which matrix stiffness …

Focal adhesions are large protein complexes organized at the basal surface of cells, which
physically connect the extracellular matrix to the cytoskeleton and have long been …

Bioprinting is an emerging technology in which cell-laden biomaterials are precisely
dispersed to engineer artificial tissues that mimic aspects of the anatomical and structural …

Photocrosslinked and biodegradable alginate hydrogels were engineered for biomedical
applications. Photocrosslinkable alginate macromers were prepared by reacting sodium …

Mesenchymal stem cells (MSCs) cultured on extracellular matrices with different stiffness
have been shown to possess diverse lineage commitment owing to the extracellular …

Bone tissue forms and is remodeled in response to the mechanical forces that it
experiences, a phenomenon described by Wolff's Law. Mechanically induced formation and …