Inherited retinal diseases (IRD) are a leading cause of blindness in the working age
population and in children. The scope of this review is to familiarise clinicians and scientists …

The ABCA4 protein (then called a “rim protein”) was first identified in 1978 in the rims and
incisures of rod photoreceptors. The corresponding gene, ABCA4, was cloned in 1997, and …

Naturally occurring stem cells isolated from humans have been used therapeutically for
decades. This has primarily involved the transplantation of primary cells such as …

Causes of blindness differ across the globe; in higher-income countries, most blindness
results from the degeneration of specific classes of cells in the retina, including retinal …

Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous group of
disorders characterised by photoreceptor degeneration or dysfunction. These disorders …

Retinitis pigmentosa (RP) is the most common cause of inherited blindness and is
characterised by the progressive loss of retinal photoreceptors. However, RP is a highly …

Pluripotent stem cells (PSCs) hold great potential for novel therapeutic approaches to
regenerate or replace functionally impaired tissues. Since the introduction of the induced …

Immune attacks are key issues for cell transplantation. To assess the safety and the immune
reactions after iPS cells-derived retinal pigment epithelium (iPS-RPE) transplantation, we …

The mammalian retina displays no intrinsic regenerative capacities, therefore retinal
degenerative diseases such as age-related macular degeneration (AMD) or retinitis …

Fundus-controlled perimetry (FCP, also called 'microperimetry') allows for spatially-resolved
map** of visual sensitivity and measurement of fixation stability, both in clinical practice as …