Cisplatin has dramatically improved the survival rate of cancer patients, but it has also
increased the prevalence of hearing and neurological deficits in this population. Cisplatin …

Oxygen metabolism in the mitochondria is essential for biological activity, and reactive
oxygen species (ROS) are produced simultaneously in the cell. Once an imbalance between …

Oxidative stress is a key component in carcinogenesis. Although radiation produces reactive
oxygen species, some anticancer agents such as alkylating agents, platinum and antitumor …

Cisplatin is a chemotherapeutic agent widely used in the treatment of various cancers.
However, cisplatin can induce nephrotoxicity and neurotoxicity, limiting its dosage and …

Ionic liquids are a diverse range of charged chemicals with low volatility and often liquids at
ambient temperatures. This characteristic has in part lead to them being considered …

Cisplatin, a small platinum-containing molecule, is a widely used, highly effective anticancer
drug. However, severe side effects have been found in cancer patients treated with cisplatin …

Loss of auditory sensory hair cells (HCs) is the most common cause of hearing loss. This
review addresses the signaling pathways that are involved in the programmed and necrotic …

Alpha-lipoic acid (α-LA) is a potent antioxidant that can prevent apoptosis associated with
cisplatin-induced ototoxicity through ROS. Ferroptosis is defined as an iron-dependent cell …

Cisplatin is a widely used anti-cancer drug used to treat a variety of cancer types. One of the
side effects of this life-saving drug is irreversible ototoxicity, resulting in permanent hearing …

The loss of auditory sensory hair cells (HCs) is the most common cause of sensorineural
hearing loss (SNHL). As the main sound transmission structure in the cochlea, it is …