Brain-gut-microbiota axis in Alzheimer's disease

K Kowalski, A Mulak - Journal of neurogastroenterology and …, 2019 - pmc.ncbi.nlm.nih.gov
Disturbances along the brain-gut-microbiota axis may significantly contribute to the
pathogenesis of neurodegenerative disorders. Alzheimer's disease (AD) is the most frequent …

Gram-negative bacteria and their lipopolysaccharides in Alzheimer's disease: pathologic roles and therapeutic implications

H Kim, S Kim, SJ Shin, YH Park, Y Nam, C Kim… - Translational …, 2021 - Springer
Alzheimer's disease (AD) is the most serious age-related neurodegenerative disease and
causes destructive and irreversible cognitive decline. Failures in the development of …

Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

SG Chen, V Stribinskis, MJ Rane, DR Demuth… - Scientific reports, 2016 - nature.com
Misfolded alpha-synuclein (AS) and other neurodegenerative disorder proteins display prion-
like transmission of protein aggregation. Factors responsible for the initiation of AS …

Mechanisms of molecular mimicry involving the microbiota in neurodegeneration

RP Friedland - Journal of Alzheimer's Disease, 2015 - content.iospress.com
The concept of molecular mimicry was established to explain commonalities of structure
which developed in response to evolutionary pressures. Most examples of molecular …

Exploring pathological link between antimicrobial and amyloid peptides

Y Tang, Y Zhang, D Zhang, Y Liu, R Nussinov… - Chemical Society …, 2024 - pubs.rsc.org
Amyloid peptides (AMYs) and antimicrobial peptides (AMPs) are considered as the two
distinct families of peptides, characterized by their unique sequences, structures, biological …

Curli biogenesis and function

MM Barnhart, MR Chapman - Annu. Rev. Microbiol., 2006 - annualreviews.org
Curli are the major proteinaceous component of a complex extracellular matrix produced by
many Enterobacteriaceae. Curli were first discovered in the late 1980s on Escherichia coli …

Functional amyloid–from bacteria to humans

DM Fowler, AV Koulov, WE Balch, JW Kelly - Trends in biochemical …, 2007 - cell.com
Amyloid–a fibrillar, cross β-sheet quaternary structure–was first discovered in the context of
human disease and tissue damage, and was thought to always be detrimental to the host …

Self-assembled peptide nanostructures: the design of molecular building blocks and their technological utilization

E Gazit - Chemical Society Reviews, 2007 - pubs.rsc.org
In this tutorial review the process and applications of peptide self-assembly into nanotubes,
nanospheres, nanofibrils, nanotapes, and other ordered structures at the nano-scale are …

Bacterial adhesins in host-microbe interactions

KA Kline, S Fälker, S Dahlberg, S Normark… - Cell host & …, 2009 - cell.com
Most commensal and pathogenic bacteria interacting with eukaryotic hosts express
adhesive molecules on their surfaces that promote interaction with host cell receptors or with …

The gut-brain axis in multiple sclerosis. Is its dysfunction a pathological trigger or a consequence of the disease?

B Parodi, N Kerlero de Rosbo - Frontiers in immunology, 2021 - frontiersin.org
A large and expending body of evidence indicates that the gut-brain axis likely plays a
crucial role in neurological diseases, including multiple sclerosis (MS). As a whole, the gut …