Random walk models in the life sciences: including births, deaths and local interactions
Random walks and related spatial stochastic models have been used in a range of
application areas, including animal and plant ecology, infectious disease epidemiology …
application areas, including animal and plant ecology, infectious disease epidemiology …
Designing policies to promote the adoption of digital phytosanitation towards sustainability: The case of the olive sector in Andalusia
CONTEXT Digital phytosanitation is at the forefront of the Agriculture 4.0 revolution, using
digital technologies and data-driven approaches for effective pest and disease …
digital technologies and data-driven approaches for effective pest and disease …
[HTML][HTML] Model-driven optimal experimental design for calibrating cardiac electrophysiology models
Abstract Background and Objective: Models of the cardiomyocyte action potential have
contributed immensely to the understanding of heart function, pathophysiology, and the …
contributed immensely to the understanding of heart function, pathophysiology, and the …
Structured methods for parameter inference and uncertainty quantification for mechanistic models in the life sciences
Parameter inference and uncertainty quantification are important steps when relating
mathematical models to real-world observations and when estimating uncertainty in model …
mathematical models to real-world observations and when estimating uncertainty in model …
Optimal experimental designs for characterising ion channel gating by filling the phase-voltage space of model dynamics
Voltage-clamp waveforms are imposed in the patch-clamp electrophysiology technique to
provoke ion currents, the particular waveform that is used is known as the “voltage-clamp …
provoke ion currents, the particular waveform that is used is known as the “voltage-clamp …
Continuation methods as a tool for parameter inference in electrophysiology modeling
MJ Owen, GR Mirams - arxiv preprint arxiv:2501.08355, 2025 - arxiv.org
Parameterizing mathematical models of biological systems often requires fitting to stable
periodic data. In cardiac electrophysiology this typically requires converging to a stable …
periodic data. In cardiac electrophysiology this typically requires converging to a stable …
Reconstructing ventricular cardiomyocyte dynamics and parameter estimation using data assimilation
Cardiac ventricular myocyte action potential dynamics are regulated by intricate and
nonlinear interactions between the cell transmembrane potential and ionic currents and …
nonlinear interactions between the cell transmembrane potential and ionic currents and …
Evaluating the predictive accuracy of ion channel models using data from multiple experimental designs
JG Shuttleworth, CL Lei, MJ Windley, AP Hill… - bioRxiv, 2024 - biorxiv.org
Mathematical models are increasingly being relied upon to provide quantitatively accurate
predictions of cardiac electrophysiology. Many such models concern the behaviour of …
predictions of cardiac electrophysiology. Many such models concern the behaviour of …
A range of voltage-clamp protocol designs for rapid capture of hERG kinetics
We provide details of a series of short voltage-clamp protocols designed for gathering a
large amount of information on hERG (Kv11. 1) ion channel gating. The protocols have a …
large amount of information on hERG (Kv11. 1) ion channel gating. The protocols have a …
[PDF][PDF] Empirical Approach on Uncertainty Analysis of Differential Equations in Mathematical Modeling
P Kaur - Sch J Phys Math Stat, 2023 - saspublishers.com
Uncertainty theory, introduced by Professor Baoding Liu of Tsinghua University in China in
2007, has lately made significant progress. It serves as an advanced and adaptable …
2007, has lately made significant progress. It serves as an advanced and adaptable …