Since the last century, peptides have gained wide acceptance as drugs, with almost 100
already in the market and a large number in the pipeline. In this context, peptide synthesis …

The present review offers an overview of nonclassical (eg, with no pre-or in situ activation of
a carboxylic acid partner) approaches for the construction of amide bonds. The review aims …

Macrocycles occupy a unique segment of chemical space. In the past decade, their chemical
diversity expanded significantly, supported by advances in bioinformatics and synthetic …

Peptides are gaining considerable attention as potential drugs. The so-called Fmoc/tBu solid-
phase synthesis is the method of choice for the synthesis of these molecules in both …

Cyclic peptides are molecules that are already used as drugs in therapies approved for
various pharmacological activities, for example, as antibiotics, antifungals, anticancer, and …

It is shown for the first time that N-sulfonyl amides can be efficiently prepared by an
unconventional approach of the hydrative reaction between terminal alkynes, sulfonyl …

▪ Abstract Proteins have become accessible targets for chemical synthesis. The basic
strategy is to use native chemical ligation, Staudinger ligation, or other orthogonal chemical …

CM (ChemMatrix) resin is a new, totally poly (ethylene glycol)(PEG)-based resin, made
exclusively from primary ether bonds and, therefore, highly chemically stable. It exhibits …

Peptides are molecules of paramount importance in the fields of health care and nutrition.
Several technologies for their production are now available, among which chemical and …

Collagen model peptides (CMPs), composed of proline–(2 S, 4 R)-hydroxyproline–glycine
(POG) repeat units, have been extensively used to study the structure and stability of triple …