A guide to the organ-on-a-chip
Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …
Immunotherapy discovery on tumor organoid-on-a-chip platforms that recapitulate the tumor microenvironment
Cancer immunotherapy has achieved remarkable success over the past decade by
modulating patients' own immune systems and unleashing pre-existing immunity. However …
modulating patients' own immune systems and unleashing pre-existing immunity. However …
Tumor spheroid-on-a-chip: a standardized microfluidic culture platform for investigating tumor angiogenesis
The field of microfluidics-based three-dimensional (3D) cell culture system is rapidly
progressing from academic proof-of-concept studies to valid solutions to real-world …
progressing from academic proof-of-concept studies to valid solutions to real-world …
3D cancer models: One step closer to in vitro human studies
N Manduca, E Maccafeo, R De Maria, A Sistigu… - Frontiers in …, 2023 - frontiersin.org
Cancer immunotherapy is the great breakthrough in cancer treatment as it displayed
prolonged progression-free survival over conventional therapies, yet, to date, in only a …
prolonged progression-free survival over conventional therapies, yet, to date, in only a …
Micro-engineering and nano-engineering approaches to investigate tumour ecosystems
The interactions among tumour cells, the tumour microenvironment (TME) and non-tumour
tissues are of interest to many cancer researchers. Micro-engineering approaches and …
tissues are of interest to many cancer researchers. Micro-engineering approaches and …
A microfluidic platform for cultivating ovarian cancer spheroids and testing their responses to chemotherapies
There is increasing interest in utilizing in vitro cultures as patient avatars to develop
personalized treatment for cancer. Typical cultures utilize Matrigel-coated plates and media …
personalized treatment for cancer. Typical cultures utilize Matrigel-coated plates and media …
3D tumor spheroid microarray for high-throughput, high-content natural killer cell-mediated cytotoxicity
Immunotherapy has emerged as a promising approach to treating several forms of cancer.
Use of immune cells, such as natural killer (NK) cells, along with small molecule drugs and …
Use of immune cells, such as natural killer (NK) cells, along with small molecule drugs and …
[HTML][HTML] Immunocompetent cancer-on-chip models to assess immuno-oncology therapy
The advances in cancer immunotherapy come with several obstacles, limiting its
widespread use and benefits so far only to a small subset of patients. One of the underlying …
widespread use and benefits so far only to a small subset of patients. One of the underlying …
Proteinaceous hydrogels for bioengineering advanced 3D tumor models
The establishment of tumor microenvironment using biomimetic in vitro models that
recapitulate key tumor hallmarks including the tumor supporting extracellular matrix (ECM) is …
recapitulate key tumor hallmarks including the tumor supporting extracellular matrix (ECM) is …
Engineering organ-on-a-chip to accelerate translational research
We guide the use of organ-on-chip technology in tissue engineering applications. Organ-on-
chip technology is a form of microengineered cell culture platform that elaborates the in-vivo …
chip technology is a form of microengineered cell culture platform that elaborates the in-vivo …