Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

The ultimate objective of biomedical research is to connect human diseases with the genes
that underlie them and drugs that treat them. But this remains a daunting task, and even the …

Genomics, epigenomics, transcriptomics, proteomics and metabolomics efforts rapidly
generate a plethora of data on the activity and levels of biomolecules within mammalian …

DNA microarrays can be used to identify gene expression changes characteristic of human
disease. This is challenging, however, when relevant differences are subtle at the level of …

There is growing recognition that mammalian cells produce many thousands of large
intergenic transcripts,,,. However, the functional significance of these transcripts has been …

The tissue-specific pattern of mRNA expression can indicate important clues about gene
function. High-density oligonucleotide arrays offer the opportunity to examine patterns of …

To derive a global perspective on the transcription of microRNAs (miRNAs) in mammals, we
annotated the genomic position and context of this class of noncoding RNAs (ncRNAs) in …

In mammals, circadian control of physiology and behavior is driven by a master pacemaker
located in the suprachiasmatic nuclei (SCN) of the hypothalamus. We have used gene …

In this paper we present a new methodology of class discovery and clustering validation
tailored to the task of analyzing gene expression data. The method can best be thought of as …

Neuroblastoma is a malignancy of the develo** sympathetic nervous system that often
presents with widespread metastatic disease, resulting in survival rates of less than 50%. To …