Biomolecular condensates and cancer
Malignant transformation is characterized by dysregulation of diverse cellular processes that
have been the subject of detailed genetic, biochemical, and structural studies, but only …
have been the subject of detailed genetic, biochemical, and structural studies, but only …
Targeting biomolecular condensation and protein aggregation against cancer
Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …
separation, hold dichotomous roles in health and disease. Alongside their physiological …
Transcription regulation by biomolecular condensates
Biomolecular condensates regulate transcription by dynamically compartmentalizing the
transcription machinery. Classic models of transcription regulation focus on the recruitment …
transcription machinery. Classic models of transcription regulation focus on the recruitment …
Modulating α-Synuclein Liquid–Liquid Phase Separation: Published as part of the Biochemistry virtual special issue “Protein Condensates”
Liquid–liquid phase separation (LLPS) is a crucial phenomenon for the formation of
functional membraneless organelles. However, LLPS is also responsible for protein …
functional membraneless organelles. However, LLPS is also responsible for protein …
Post-translational modifications in liquid-liquid phase separation: a comprehensive review
Liquid-liquid phase separation (LLPS) has received significant attention in recent biological
studies. It refers to a phenomenon that biomolecule exceeds the solubility, condensates and …
studies. It refers to a phenomenon that biomolecule exceeds the solubility, condensates and …
[HTML][HTML] Liquid-liquid phase separation as a common organizing principle of intracellular space and biomembranes providing dynamic adaptive responses
This work is devoted to the phenomenon of liquid-liquid phase separation (LLPS), which has
come to be recognized as fundamental organizing principle of living cells. We distinguish …
come to be recognized as fundamental organizing principle of living cells. We distinguish …
[HTML][HTML] Biomolecular condensates at sites of DNA damage: more than just a phase
V Spegg, M Altmeyer - DNA repair, 2021 - Elsevier
Protein recruitment to DNA break sites is an integral part of the DNA damage response
(DDR). Elucidation of the hierarchy and temporal order with which DNA damage sensors as …
(DDR). Elucidation of the hierarchy and temporal order with which DNA damage sensors as …
Phase separations in oncogenesis, tumor progressions and metastasis: a glance from hallmarks of cancer
LW Zheng, CC Liu, KD Yu - Journal of Hematology & Oncology, 2023 - Springer
Liquid–liquid phase separation (LLPS) is a novel principle for interpreting precise
spatiotemporal coordination in living cells through biomolecular condensate (BMC) …
spatiotemporal coordination in living cells through biomolecular condensate (BMC) …
Emerging roles of liquid–liquid phase separation in cancer: from protein aggregation to immune-associated signaling
J Lu, J Qian, Z Xu, S Yin, L Zhou, S Zheng… - Frontiers in cell and …, 2021 - frontiersin.org
Liquid–liquid Phase Separation (LLPS) of proteins and nucleic acids has emerged as a new
paradigm in the study of cellular activities. It drives the formation of liquid-like condensates …
paradigm in the study of cellular activities. It drives the formation of liquid-like condensates …
Phase separation of p53 precedes aggregation and is affected by oncogenic mutations and ligands
Mutant p53 tends to form aggregates with amyloid properties, especially amyloid oligomers
inside the nucleus, which are believed to cause oncogenic gain-of-function (GoF). The …
inside the nucleus, which are believed to cause oncogenic gain-of-function (GoF). The …