[HTML][HTML] Intracellular Citrate/acetyl-CoA flux and endoplasmic reticulum acetylation: Connectivity is the answer
Background Key cellular metabolites reflecting the immediate activity of metabolic enzymes
as well as the functional metabolic state of intracellular organelles can act as powerful signal …
as well as the functional metabolic state of intracellular organelles can act as powerful signal …
The citrate transporters SLC13A5 and SLC25A1 elicit different metabolic responses and phenotypes in the mouse
Cytosolic citrate is imported from the mitochondria by SLC25A1, and from the extracellular
milieu by SLC13A5. In the cytosol, citrate is used by ACLY to generate acetyl-CoA, which …
milieu by SLC13A5. In the cytosol, citrate is used by ACLY to generate acetyl-CoA, which …
Naringenin ameliorates amyloid-β pathology and neuroinflammation in Alzheimer's disease
Y Zhu, X Guo, S Li, Y Wu, F Zhu, C Qin… - Communications …, 2024 - nature.com
Alzheimer's disease (AD) is the most common cause of dementia characterized by amyloid-
β (Aβ) deposition, tau hyperphosphorylation, and neuroinflammation. Naringenin (NRG), a …
β (Aβ) deposition, tau hyperphosphorylation, and neuroinflammation. Naringenin (NRG), a …
Protein restriction slows the development and progression of pathology in a mouse model of Alzheimer's disease
R Babygirija, MM Sonsalla, J Mill, I James… - Nature …, 2024 - nature.com
Dietary protein is a critical regulator of metabolic health and aging. Low protein diets are
associated with healthy aging in humans, and dietary protein restriction extends the lifespan …
associated with healthy aging in humans, and dietary protein restriction extends the lifespan …
Increased expression of SLC25A1/CIC causes an autistic-like phenotype with altered neuron morphology
N ε-lysine acetylation within the lumen of the endoplasmic reticulum is a recently
characterized protein quality control system that positively selects properly folded …
characterized protein quality control system that positively selects properly folded …
SLC13A5/sodium-citrate co-transporter overexpression causes disrupted white matter integrity and an autistic-like phenotype
Endoplasmic reticulum-based N ɛ-lysine acetylation serves as an important protein quality
control system for the secretory pathway. Dysfunctional endoplasmic reticulum-based …
control system for the secretory pathway. Dysfunctional endoplasmic reticulum-based …
Ca+2 and Nε-lysine acetylation regulate the CALR-ATG9A interaction in the lumen of the endoplasmic reticulum
MM Braun, BK Sheehan, SL Shapiro, Y Ding… - Scientific Reports, 2024 - nature.com
The acetylation of autophagy protein 9 A (ATG9A) in the lumen of the endoplasmic reticulum
(ER) by ATase1 and ATase2 regulates the induction of reticulophagy. Analysis of the ER …
(ER) by ATase1 and ATase2 regulates the induction of reticulophagy. Analysis of the ER …
Protein restriction slows the development and progression of Alzheimer's disease in mice
R Babygirija, MM Sonsalla, J Mill, I James… - Research …, 2024 - pmc.ncbi.nlm.nih.gov
Dietary protein is a critical regulator of metabolic health and aging. Low protein diets are
associated with healthy aging in humans, and many independent groups of researchers …
associated with healthy aging in humans, and many independent groups of researchers …
ATase inhibition rescues age-associated proteotoxicity of the secretory pathway
Malfunction of autophagy contributes to the progression of many chronic age-associated
diseases. As such, improving normal proteostatic mechanisms is an active target for …
diseases. As such, improving normal proteostatic mechanisms is an active target for …
Spatial selectivity of ATase inhibition in mouse models of Charcot–Marie–Tooth disease
The endoplasmic reticulum acetylation machinery has emerged as a new branch of the
larger endoplasmic reticulum quality control system. It regulates the selection of correctly …
larger endoplasmic reticulum quality control system. It regulates the selection of correctly …