Biochemistry textbooks and cell culture experiments seem to be telling us two different
things about the significance of external glutamine supply for mammalian cell growth and …

The transition metal iron is essential for life, yet potentially toxic iron-catalyzed reactive
oxygen species (ROS) are unavoidable in an oxygen-rich environment. Iron and ROS are …

In this study we interrogated the metabolome of human acute myeloid leukemia (AML) stem
cells to elucidate properties relevant to therapeutic intervention. We demonstrate that amino …

Although Michael acceptors display a potent and broad spectrum of bioactivity, they have
largely been ignored in drug discovery because of their presumed indiscriminate reactivity …

Like normal hematopoietic stem cells, leukemic stem cells depend on their bone marrow
(BM) microenvironment for survival, but the underlying mechanisms remain largely …

An appropriate balance between self-renewal and differentiation is crucial for stem cell
function during both early development and tissue homeostasis throughout life. Recent …

Malignant stem cells have long been considered a key therapeutic target in leukemia.
Therapeutic strategies designed to target the fundamental biology of leukemia stem cells …

For more than 50 years, investigators have considered a malignant stem cell as the potential
origin of and a key therapeutic target for acute myeloid leukemia (AML) and other forms of …

Acute myeloid leukemia (AML) is characterized by the presence of leukemia stem cells
(LSCs), and failure to fully eradicate this population contributes to disease …

Reactive oxygen species (ROS) play an important role in determining the fate of normal
stem cells. Low levels of ROS are required for stem cells to maintain quiescence and self …