EGF–ERBB signalling: towards the systems level
A Citri, Y Yarden - Nature reviews Molecular cell biology, 2006 - nature.com
Signalling through the ERBB/HER receptors is intricately involved in human cancer and
already serves as a target for several cancer drugs. Because of its inherent complexity, it is …
already serves as a target for several cancer drugs. Because of its inherent complexity, it is …
Gene regulatory networks and the evolution of animal body plans
EH Davidson, DH Erwin - Science, 2006 - science.org
Development of the animal body plan is controlled by large gene regulatory networks
(GRNs), and hence evolution of body plans must depend upon change in the architecture of …
(GRNs), and hence evolution of body plans must depend upon change in the architecture of …
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
U Sahin, G Weskamp, K Kelly, HM Zhou… - The Journal of cell …, 2004 - rupress.org
All ligands of the epidermal growth factor receptor (EGFR), which has important roles in
development and disease, are released from the membrane by proteases. In several …
development and disease, are released from the membrane by proteases. In several …
Inter-cell type interactions that control JNK signaling in the Drosophila intestine
JNK signaling is a critical regulator of inflammation and regeneration, but how it is controlled
in specific tissue contexts remains unclear. Here we show that, in the Drosophila intestine …
in specific tissue contexts remains unclear. Here we show that, in the Drosophila intestine …
LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation
Kekkon proteins negatively regulate the epidermal growth factor receptor (EGFR) during
oogenesis in Drosophila. Their structural relative in mammals, LRIG1, is a transmembrane …
oogenesis in Drosophila. Their structural relative in mammals, LRIG1, is a transmembrane …
[HTML][HTML] EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells
N Xu, SQ Wang, D Tan, Y Gao, G Lin, R ** studies …
The Capicua repressor–a general sensor of RTK signaling in development and disease
G Jiménez, SY Shvartsman… - Journal of cell …, 2012 - journals.biologists.com
Receptor tyrosine kinase (RTK) signaling pathways control multiple cellular decisions in
metazoans, often by regulating the expression of downstream genes. In Drosophila …
metazoans, often by regulating the expression of downstream genes. In Drosophila …
The RTK interactome: overview and perspective on RTK heterointeractions
Receptor tyrosine kinases (RTKs) play important roles in cell growth, motility, differentiation,
and survival. These single-pass membrane proteins are grouped into subfamilies based on …
and survival. These single-pass membrane proteins are grouped into subfamilies based on …
Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila
K Foltenyi, RJ Greenspan, JW Newport - Nature neuroscience, 2007 - nature.com
Epidermal growth factor receptor (EGFR) signaling in the mammalian hypothalamus is
important in the circadian regulation of activity. We have examined the role of this pathway in …
important in the circadian regulation of activity. We have examined the role of this pathway in …