SARS-CoV-2 and innate immunity: the good, the bad, and the “goldilocks”
An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …
immunity. Knowledge about this interplay can not only help us identify biological …
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance
In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like
(APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven …
(APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven …
Human APOBEC3 variations and viral infection
Human APOBEC3 (apolipoprotein B mRNA-editing catalytic polypeptide-like 3) enzymes
are capable of inhibiting a wide range of endogenous and exogenous viruses using …
are capable of inhibiting a wide range of endogenous and exogenous viruses using …
[HTML][HTML] The structural basis for HIV-1 Vif antagonism of human APOBEC3G
Abstract The APOBEC3 (A3) proteins are host antiviral cellular proteins that hypermutate the
viral genome of diverse viral families. In retroviruses, this process requires A3 packaging …
viral genome of diverse viral families. In retroviruses, this process requires A3 packaging …
[HTML][HTML] APOBECs orchestrate genomic and epigenomic editing across health and disease
K Cervantes-Gracia, A Gramalla-Schmitz… - Trends in Genetics, 2021 - cell.com
APOBEC proteins can deaminate cytosine residues in DNA and RNA. This can lead to
somatic mutations, DNA breaks, RNA modifications, or DNA demethylation in a selective …
somatic mutations, DNA breaks, RNA modifications, or DNA demethylation in a selective …
Nanocomposites based on polylactide and silver nanoparticles and their antimicrobial and antiviral applications
Novel antimicrobial and antiviral silver-containing nanocomposites (PLA-Ag-PEI) based on
polylactide (PLA) have been created by the thermochemical reduction of Ag+ ions in the …
polylactide (PLA) have been created by the thermochemical reduction of Ag+ ions in the …
APOBEC3 degradation is the primary function of HIV-1 Vif determining virion infectivity in the myeloid cell line THP-1
ABSTRACT HIV-1 must overcome multiple innate antiviral mechanisms to replicate in CD4+
T lymphocytes and macrophages. Previous studies have demonstrated that the …
T lymphocytes and macrophages. Previous studies have demonstrated that the …
Competition for DNA binding between the genome protector replication protein A and the genome modifying APOBEC3 single-stranded DNA deaminases
The human APOBEC family of eleven cytosine deaminases use RNA and single-stranded
DNA (ssDNA) as substrates to deaminate cytosine to uracil. This deamination event has …
DNA (ssDNA) as substrates to deaminate cytosine to uracil. This deamination event has …
The current toolbox for APOBEC drug discovery
MJ Grillo, KFM Jones, MA Carpenter, RS Harris… - Trends in …, 2022 - cell.com
Mutational processes driving genome evolution and heterogeneity contribute to immune
evasion and therapy resistance in viral infections and cancer. APOBEC3 (A3) enzymes …
evasion and therapy resistance in viral infections and cancer. APOBEC3 (A3) enzymes …
Restriction factors regulating human herpesvirus infections
MC Serrero, SR Paludan - Trends in Immunology, 2024 - cell.com
Herpesviruses are DNA viruses and the cause of diseases ranging from mild skin conditions
to severe brain diseases. Mammalian antiviral host defense comprises an array of …
to severe brain diseases. Mammalian antiviral host defense comprises an array of …