Serotonin modulation of prefronto-hippocampal rhythms in health and disease

MV Puig, T Gener - ACS chemical neuroscience, 2015 - ACS Publications
There is mounting evidence that most cognitive functions depend upon the coordinated
activity of neuronal networks often located far from each other in the brain. Ensembles of …

Intermediate phenotypes and biomarkers of treatment outcome in major depressive disorder

AF Leuchter, AM Hunter, DE Krantz… - Dialogues in clinical …, 2014 - Taylor & Francis
Major depressive disorder (MDD) is a pleomorphic illness originating from gene x
environment interactions. Patients with differing symptom phenotypes receive the same …

Altered resting-state EEG source functional connectivity in schizophrenia: the effect of illness duration

G Di Lorenzo, A Daverio, F Ferrentino… - Frontiers in human …, 2015 - frontiersin.org
Despite the increasing body of evidence supporting the hypothesis of schizophrenia as a
disconnection syndrome, studies of resting-state EEG Source Functional Connectivity (EEG …

[HTML][HTML] Opportunities for multiscale computational modelling of serotonergic drug effects in Alzheimer's disease

A Joshi, DH Wang, S Watterson, PL McClean… - …, 2020 - Elsevier
Alzheimer's disease (AD) is an age-specific neurodegenerative disease that compromises
cognitive functioning and impacts the quality of life of an individual. Pathologically, AD is …

Toward a multiscale modeling framework for understanding serotonergic function

KF Wong-Lin, DH Wang, AA Moustafa… - Journal of …, 2017 - journals.sagepub.com
Despite its importance in regulating emotion and mental wellbeing, the complex structure
and function of the serotonergic system present formidable challenges toward …

[HTML][HTML] Neonatal hypoxia impairs serotonin release and cognitive functions in adult mice

KKY Lee, B Chattopadhyaya, ASF do Nascimento… - Neurobiology of …, 2024 - Elsevier
Children who experienced moderate perinatal asphyxia (MPA) are at risk of develo** long
lasting subtle cognitive and behavioral deficits, including learning disabilities and emotional …

Unveiling serotonergic dysfunction of obsessive-compulsive disorder on prefrontal network dynamics: a computational perspective

L Yin, Y Yu, F Han, Q Wang - Cerebral Cortex, 2024 - academic.oup.com
Abstract Serotonin (5-HT) regulates working memory within the prefrontal cortex network,
which is crucial for understanding obsessive-compulsive disorder. However, the …

An integrated modelling framework for neural circuits with multiple neuromodulators

A Joshi, V Youssofzadeh, V Vemana… - Journal of the …, 2017 - royalsocietypublishing.org
Neuromodulators are endogenous neurochemicals that regulate biophysical and
biochemical processes, which control brain function and behaviour, and are often the targets …

Neuropharmacology of altered brain oscillations in schizophrenia

M Koch, C Schmiedt-Fehr, B Mathes - International Journal of …, 2016 - Elsevier
Impairments in spatial and temporal integration of brain network activity are a core feature of
schizophrenia. Neural network oscillatory activity is considered to be fundamentally …

Integrated dopaminergic neuronal model with reduced intracellular processes and inhibitory autoreceptors

M Cullen, KF Wong‐Lin - IET Systems Biology, 2015 - Wiley Online Library
Dopamine (DA) is an important neurotransmitter for multiple brain functions, and
dysfunctions of the dopaminergic system are implicated in neurological and …