Most neurodegenerative disorders are associated with aggregated protein deposits. In the
case of Alzheimer disease (AD), extracellular amyloid-β (Aβ) aggregates and intracellular …

Alzheimer's disease (AD) is a slowly progressing disorder in which pathophysiological
abnormalities, detectable in vivo by biomarkers, precede overt clinical symptoms by many …

Summary Background Models of Alzheimer's disease propose a sequence of amyloid β (Aβ)
accumulation, hypometabolism, and structural decline that precedes the onset of clinical …

Multifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly
characterized from an integrative perspective. Here spatiotemporal alterations in brain …

In 2010, we put forward a hypothetical model of the major biomarkers of Alzheimer's disease
(AD). The model was received with interest because we described the temporal evolution of …

Objective: Using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI)
population, we examined (1) cross‐sectional relationships between amyloid deposition …

Alzheimer's disease is a progressive neurodegenerative disease that typically manifests
clinically as an isolated amnestic deficit that progresses to a characteristic dementia …

Major imaging biomarkers of Alzheimer's disease include amyloid deposition [imaged with
[11C] Pittsburgh compound B (PiB) PET], altered glucose metabolism (imaged with [18F] …

We demonstrate the use of a probabilistic generative model to explore the biomarker
changes occurring as Alzheimer's disease develops and progresses. We enhanced the …

In 2010, the authors published a hypothetical model of the major biomarkers of Alzheimer's
disease (AD). The model was received with interest because we described the temporal …