Mechanisms of podocyte injury and implications for diabetic nephropathy
F Barutta, S Bellini, G Gruden - Clinical Science, 2022 - portlandpress.com
Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …
Host factors predisposing to kidney disease in people with HIV
RKY Hung, CA Winkler, FA Post - Current Opinion in HIV and …, 2023 - journals.lww.com
Genetic variants of APOL1 are strongly associated with severe CKD and contribute to the
high rates of CKD in Black populations with HIV. Most individuals with APOL1 kidney-risk …
high rates of CKD in Black populations with HIV. Most individuals with APOL1 kidney-risk …
[HTML][HTML] HDL and chronic kidney disease
C Pavanello, A Ossoli - Atherosclerosis Plus, 2023 - Elsevier
Abstract Low HDL-cholesterol (HDL-C) concentrations are a typical trait of the dyslipidemia
associated with chronic kidney disease (CKD). In this condition, plasma HDLs are …
associated with chronic kidney disease (CKD). In this condition, plasma HDLs are …
Dyes-encapsulated metal-organic cage as fluorescence sensor array for the auxiliary differential diagnosis of MCD and FSGS in early renal disorders
J Fan, J Zhang, X Yang, M Jia, B Zhang, W Zhao… - Biosensors and …, 2025 - Elsevier
Both minimal change disease (MCD) and focal segmental glomerular sclerosis (FSGS) are
the pathological types of primary nephrotic syndrome (PNS) and cannot be readily …
the pathological types of primary nephrotic syndrome (PNS) and cannot be readily …
[HTML][HTML] APOL1 promotes endothelial cell activation beyond the glomerulus
M Carracedo, E Ericson, R Ågren, A Forslöw… - Iscience, 2023 - cell.com
Summary Apolipoprotein L1 (APOL1) high-risk genotypes are associated with increased risk
of chronic kidney disease (CKD) in people of West African ancestry. Given the importance of …
of chronic kidney disease (CKD) in people of West African ancestry. Given the importance of …
[HTML][HTML] APOL1 kidney risk variants in glomerular diseases modeled in transgenic mice
APOL1 high-risk variants partially explain the high kidney disease prevalence among
African ancestry individuals. Many mechanisms have been reported in cell culture models …
African ancestry individuals. Many mechanisms have been reported in cell culture models …
Single-Cell Transcriptional Signatures of Glomerular Disease in Transgenic Mice with APOL1 Variants
Background APOL1 high-risk variants contribute to kidney disease among African-ancestry
individuals. We sought to describe cell-specific APOL1 variants-induced pathways using two …
individuals. We sought to describe cell-specific APOL1 variants-induced pathways using two …
Endothelial cell-specific molecule-1 inhibits albuminuria in diabetic mice
X Zheng, L Higdon, A Gaudet, M Shah, A Balistieri… - Kidney360, 2022 - journals.lww.com
Background Diabetic kidney disease (DKD) is the most common cause of kidney failure in
the world, and novel predictive biomarkers and molecular mechanisms of disease are …
the world, and novel predictive biomarkers and molecular mechanisms of disease are …
[PDF][PDF] Precision medicine for focal segmental glomerulosclerosis
Y **e, F Liu - Kidney Research and Clinical Practice, 2024 - krcp-ksn.org
Focal segmental glomerulosclerosis (FSGS) is one of the common causes of nephrotic
syndrome in adults and children worldwide. FSGS consists of a group of kidney diseases …
syndrome in adults and children worldwide. FSGS consists of a group of kidney diseases …
Analysis of Glomerular Transcriptomes from Nephrotic Patients Suggest APOL1 Risk Variants Impact Parietal Epithelial Cells
The disproportionate risk for idiopathic proteinuric podocytopathies in Black people is
explained, in part, by the presence of two risk alleles (G1 or G2) in the APOL1 gene. The …
explained, in part, by the presence of two risk alleles (G1 or G2) in the APOL1 gene. The …