α-and β-dystroglycan constitute a membrane-spanning complex that connects the
extracellular matrix to the cytoskeleton. Although a structural role for dystroglycan had been …

Dystroglycan is a ubiquitously expressed heterodimeric adhesion receptor. The extracellular
α-subunit makes connections with a number of laminin G domain ligands including laminins …

An active involvement of blood–brain barrier endothelial cell basement membranes in
development of inflammatory lesions in the central nervous system (CNS) has not been …

Background: We previously used a three-dimensional (3D) reconstituted basement
membrane (rBM) assay to demonstrate that tumorigenic HMT-3522 T4–2 human breast cells …

Vasogenic edema is one of the most serious clinical problems in brain tumors and tightly
connected to water shifts between the different fluid compartments in the brain. Aquaporin …

Abstract hAG-2 and hAG-3 are recently discovered human homologues of the secreted
Xenopus laevis proteins XAG-1/2 (AGR-1/2) that are expressed in the cement gland, an …

Dystroglycan, originally identified in muscle as a component of the dystrophin-associated
glycoprotein complex, is a ubiquitously expressed cell-surface receptor that forms a …

We recently identified mutations in the fukutin related protein (FKRP) gene in patients with
congenital muscular dystrophy type 1C (MDC1C) and limb girdle muscular dystrophy type 2I …

Receptors mediating cell-basement membrane interactions are potent regulators of
epithelial architecture and function, and alterations in signals from the basement membrane …

The dystroglycan complex is a membrane-spanning complex composed of two subunits, α-
and β-dystroglycan. α-dystroglycan is a cell surface peripheral membrane protein which …