Epigenetic modifications of major depressive disorder
Major depressive disorder (MDD) is a chronic disease whose neurological basis and
pathophysiology remain poorly understood. Initially, it was proposed that genetic variations …
pathophysiology remain poorly understood. Initially, it was proposed that genetic variations …
Advances toward precision medicine for bipolar disorder: mechanisms & molecules
Given its chronicity, contribution to disability and morbidity, and prevalence of more than 2%,
the effective treatment, and prevention of bipolar disorder represents an area of significant …
the effective treatment, and prevention of bipolar disorder represents an area of significant …
Animal models of bipolar mania: the past, present and future
Bipolar disorder (BD) is the sixth leading cause of disability in the world according to the
World Health Organization and affects nearly six million (∼ 2.5% of the population) adults in …
World Health Organization and affects nearly six million (∼ 2.5% of the population) adults in …
A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests
Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are
projected to lead global disease burden within the next decade. Pharmacotherapy, the …
projected to lead global disease burden within the next decade. Pharmacotherapy, the …
Epigenetic landscape of amphetamine and methamphetamine addiction in rodents
Amphetamine and methamphetamine addiction is described by specific behavioral
alterations, suggesting long-lasting changes in gene and protein expression within specific …
alterations, suggesting long-lasting changes in gene and protein expression within specific …
Sodium butyrate prevents memory impairment by re-establishing BDNF and GDNF expression in experimental pneumococcal meningitis
Pneumococcal meningitis is a serious infection of the central nervous system (CNS) with
high fatality rates that causes reduced psychomotor performance, slight mental slowness …
high fatality rates that causes reduced psychomotor performance, slight mental slowness …
Sodium butyrate and mood stabilizers block ouabain-induced hyperlocomotion and increase BDNF, NGF and GDNF levels in brain of Wistar rats
Bipolar Disorder (BD) is one of the most severe psychiatric disorders. Despite adequate
treatment, patients continue to have recurrent mood episodes, residual symptoms, and …
treatment, patients continue to have recurrent mood episodes, residual symptoms, and …
H3K4 tri-methylation in synapsin genes leads to different expression patterns in bipolar disorder and major depression
The synapsin family of neuronal phosphoproteins is composed of three genes (SYN1, SYN2
and SYN3) with alternative splicing resulting in a number of variants with various levels of …
and SYN3) with alternative splicing resulting in a number of variants with various levels of …
Linking mitochondrial dysfunction, neurotransmitter, neural network abnormalities and mania: elucidating neurobiological mechanisms of the therapeutic effect of the …
There is growing interest in the ketogenic diet as a treatment for Bipolar Disorder (BD), with
promising anecdotal and small case study reports of efficacy. Yet, the neurobiological …
promising anecdotal and small case study reports of efficacy. Yet, the neurobiological …
Epigenetics in bipolar disorder: a critical review of the literature
Methods We searched PubMed, and Embase databases and classified the articles
depending on the epigenetic mechanisms (DNA methylation, histone modifications and non …
depending on the epigenetic mechanisms (DNA methylation, histone modifications and non …