The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …

The fungal pathogens Candida albicans, Cryptococcus neoformans, and Aspergillus
fumigatus have transitioned from a rare curiosity to a leading cause of human mortality. The …

Azoles are the mainstay of oral therapy for aspergillosis. Azole resistance in Aspergillus has
been reported infrequently. The first resistant isolate was detected in 1999 in Manchester …

Fungal biofilm infections have become increasingly recognised as a significant clinical
problem. One of the major reasons behind this is the impact that these have upon treatment …

Pathogenic fungi have become a leading cause of human mortality due to the increasing
frequency of fungal infections in immunocompromised populations and the limited …

Fungi cause serious infections in the immunocompromised and debilitated, and the
incidence of invasive mycoses has increased significantly over the last 3 decades. Slow …

Aspergillus fumigatus is the main causal agent of invasive aspergillosis (IA), however other
species of the genus can also cause IA, such as Aspergillus flavus, Aspergillus terreus …

Fourteen Aspergillus fumigatus clinical isolates that exhibited a pattern of reduced
susceptibility to triazole drugs were analyzed. The sequences of the cyp51A gene from all …

We reported the emergence of resistance to medical triazoles of Aspergillus fumigatus
isolates from patients with invasive aspergillosis. A dominant resistance mechanism was …

The emergence of drug resistance in pathogenic microorganisms provides an excellent
example of microbial evolution that has had profound consequences for human health. The …