Revisiting the role of acetylcholinesterase in Alzheimer's disease: cross-talk with P-tau and β-amyloid

MS García-Ayllón, DH Small, J Avila… - Frontiers in molecular …, 2011 - frontiersin.org
A common feature in the Alzheimer's disease (AD) brain is the presence of
acetylcholinesterase (AChE) which is commonly associated with β-amyloid plaques and …

Covert hepatic encephalopathy: not as minimal as you might think

MR Kappus, JS Bajaj - Clinical Gastroenterology and Hepatology, 2012 - Elsevier
Hepatic encephalopathy (HE) is a serious neuropsychiatric and neurocognitive complication
of acute and chronic liver disease. Symptoms are often overt (confusion, disorientation …

Grape Seed Proanthocyanidin Extract Mitigates Titanium Dioxide Nanoparticle (TiO2-NPs)–Induced Hepatotoxicity Through TLR-4/NF-κB Signaling Pathway

ET Mohammed, GM Safwat - Biological trace element research, 2020 - Springer
With the progress of nanotechnology, the adverse effects of nanoscale materials are
receiving much attention. Inhibition of toll-like receptor 4 (TLR-4)/nuclear factor kappa B (NF …

Altered levels of acetylcholinesterase in Alzheimer plasma

MS García-Ayllón, I Riba-Llena, C Serra-Basante… - PLoS …, 2010 - journals.plos.org
Background Many studies have been conducted in an extensive effort to identify alterations
in blood cholinesterase levels as a consequence of disease, including the analysis of …

Acetylcholinesterase Inhibition in Rats and Humans Following Acute Fenitrothion Exposure Predicted by Physiologically Based Kinetic Modeling-Facilitated Quantitative In Vitro …

J Chen, S Zhao, S Wesseling, NI Kramer… - Environmental …, 2023 - ACS Publications
Worldwide use of organophosphate pesticides as agricultural chemicals aims to maintain a
stable food supply, while their toxicity remains a major public health concern. A common …

Evaluation of toxic effects induced by sub-acute exposure to low doses of α-cypermethrin in adult male rats

V Kašuba, B Tariba Lovaković, A Lucić Vrdoljak… - Toxics, 2022 - mdpi.com
To contribute new information to the pyrethroid pesticide α-cypermethrin toxicity profile, we
evaluated its effects after oral administration to Wistar rats at daily doses of 2.186, 0.015 …

Neurotransmitter receptor alterations in hepatic encephalopathy: a review

N Palomero-Gallagher, K Zilles - Archives of biochemistry and biophysics, 2013 - Elsevier
Hepatic encephalopathy (HE), a complex neuropsychiatric syndrome with symptoms
ranging from subtle neuropsychiatric and motor disturbances to deep coma and death, is …

Cannabis sativa L. (var. indica) Exhibits Hepatoprotective Effects by Modulating Hepatic Lipid Profile and Mitigating Gluconeogenesis and Cholinergic Dysfunction in …

OL Erukainure, MG Matsabisa, VF Salau… - Frontiers in …, 2021 - frontiersin.org
Cannabis sativa L. is a crop utilized globally for recreational, therapeutic, and religious
purposes. Although considered as an illicit drug in most countries, C. sativa until recently …

Brain cholinergic impairment in liver failure

MS García-Ayllón, O Cauli, MX Silveyra, R Rodrigo… - Brain, 2008 - academic.oup.com
The cholinergic system is involved in specific behavioural responses and cognitive
processes. Here, we examined potential alterations in the brain levels of key cholinergic …

Ameliorative effects of honey, propolis, pollen, and royal jelly mixture against chronic toxicity of sumithion insecticide in white albino rats

AMK Nassar, YMM Salim, KSA Eid, HM Shaheen… - Molecules, 2020 - mdpi.com
Sumithion (Fenitrothion)(SUM) is an organophosphorus insecticide used to combat a wide
variety of plant pests. Exposure to SUM causes significant toxicity to the brain, liver, kidney …