Breaking the chains: deubiquitylating enzyme specificity begets function
The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases)
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …
The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication
M Tarsounas, P Sung - Nature Reviews Molecular Cell Biology, 2020 - nature.com
The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA
double-strand break (DSB) repair by homologous recombination and protects DNA …
double-strand break (DSB) repair by homologous recombination and protects DNA …
[HTML][HTML] Histone ubiquitination: an integrative signaling platform in genome stability
F Mattiroli, L Penengo - Trends in Genetics, 2021 - cell.com
Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …
Principles of ubiquitin-dependent signaling
E Oh, D Akopian, M Rape - Annual review of cell and …, 2018 - annualreviews.org
Ubiquitylation is an essential posttranslational modification that controls cell division,
differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers) …
differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers) …
USP48 is upregulated by Mettl14 to attenuate hepatocellular carcinoma via regulating SIRT6 stabilization
L Du, Y Li, M Kang, M Feng, Y Ren, H Dai, Y Wang… - Cancer research, 2021 - AACR
Exploiting cancer metabolism for the clinical benefit of patients with hepatocellular
carcinoma (HCC) is a topic under active investigation. Ubiquitin-specific peptidase 48 …
carcinoma (HCC) is a topic under active investigation. Ubiquitin-specific peptidase 48 …
BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1
Mutations in the E3 ubiquitin ligase RING domains of BRCA1/BARD1 predispose carriers to
breast and ovarian cancers. We present the structure of the BRCA1/BARD1 RING …
breast and ovarian cancers. We present the structure of the BRCA1/BARD1 RING …
Mechanisms of synthetic lethality between BRCA1/2 and 53BP1 deficiencies and DNA polymerase theta targeting
A synthetic lethal relationship exists between disruption of polymerase theta (Polθ), and loss
of either 53BP1 or homologous recombination (HR) proteins, including BRCA1; however …
of either 53BP1 or homologous recombination (HR) proteins, including BRCA1; however …
USP48 stabilizes gasdermin E to promote pyroptosis in cancer
Y Ren, M Feng, X Hao, X Liu, J Li, P Li, J Gao, Q Qi… - Cancer research, 2023 - AACR
Pyroptosis is a type of programmed cell death characterized by the activation of
inflammatory caspases and the cleavage of gasdermin proteins. Pyroptosis can suppress …
inflammatory caspases and the cleavage of gasdermin proteins. Pyroptosis can suppress …
The chromatin response to double-strand DNA breaks and their repair
Cellular DNA is constantly being damaged by numerous internal and external mutagenic
factors. Probably the most severe type of insults DNA could suffer are the double-strand …
factors. Probably the most severe type of insults DNA could suffer are the double-strand …
[HTML][HTML] OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer
J Li, D Cheng, M Zhu, H Yu, Z Pan, L Liu, Q Geng… - Theranostics, 2019 - ncbi.nlm.nih.gov
Increasing evidence has confirmed that deubiquitinating enzymes play an important role in
lung cancer progression. In the current study, we investigated the expression profile of …
lung cancer progression. In the current study, we investigated the expression profile of …