States of oral health and disease reflect the compositional and functional capacities of, as
well as the interspecies interactions within, the oral microbiota. The oral cavity exists as a …

Over the last few decades, studies on the oral microbiome have increased awareness that
the balance between the host and the microbial species that coexist in it is essential for oral …

Biofilms are surface-attached bacterial communities embedded within an extracellular matrix
that create localized and protected microenvironments. Acidogenic oral biofilms can …

Streptococcus mutans is often cited as the main bacterial pathogen in dental caries,
particularly in early-childhood caries (ECC). S. mutans may not act alone; Candida albicans …

Tooth decay (dental caries) is a widespread human disease caused by microbial biofilms.
Streptococcus mutans, a biofilm-former, has been consistently associated with severe …

The importance of Streptococcus mutans in the etiology and pathogenesis of dental caries is
certainly controversial, in part because excessive attention is paid to the numbers of S …

Many infectious diseases in humans are caused or exacerbated by biofilms. Dental caries is
a prime example of a biofilm-dependent disease, resulting from interactions of …

Biofilms are highly structured microbial communities that are enmeshed in a self-produced
extracellular matrix. Within the complex oral microbiome, Streptococcus mutans is a major …

Virulent biofilms are responsible for a range of infections, including oral diseases. All
biofilms harbor a microbial-derived extracellular-matrix. The exopolysaccharides (EPS) …

Development of effective therapies to control oral biofilms is challenging, as topically
introduced agents must avoid rapid clearance from biofilm–tooth interfaces while targeting …