Early-life stress impacts the develo** hippocampus and primes seizure occurrence: cellular, molecular, and epigenetic mechanisms

LT Huang - Frontiers in molecular neuroscience, 2014 - frontiersin.org
Early-life stress includes prenatal, postnatal, and adolescence stress. Early-life stress can
affect the development of the hypothalamic-pituitary-adrenal (HPA) axis, and cause cellular …

[HTML][HTML] The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities

K Sarkisova, G van Luijtelaar - IBRO Neuroscience Reports, 2022 - Elsevier
This review discusses the long-term effects of early-life environment on epileptogenesis,
epilepsy, and neuropsychiatric comorbidities with an emphasis on the absence epilepsy …

Sex-and exposure age-dependent effects of adolescent stress on ventral tegmental area dopamine system and its afferent regulators

X Zhu, AA Grace - Molecular psychiatry, 2023 - nature.com
Adolescent stress is a risk factor for schizophrenia. Emerging evidence suggests that age-
dependent sensitive windows for childhood trauma are associated more strongly with adult …

Kainic acid-induced post-status epilepticus models of temporal lobe epilepsy with diverging seizure phenotype and neuropathology

D Bertoglio, H Amhaoul, A Van Eetveldt… - Frontiers in …, 2017 - frontiersin.org
The aim of epilepsy models is to investigate disease ontogenesis and therapeutic
interventions in a consistent and prospective manner. The kainic acid-induced status …

Myalgic encephalomyelitis: symptoms and biomarkers

L A. Jason, M L. Zinn, M A. Zinn - Current Neuropharmacology, 2015 - benthamdirect.com
Myalgic Encephalomyelitis (ME) continues to cause significant morbidity worldwide with an
estimated one million cases in the United States. Hurdles to establishing consensus to …

Early life maternal separation stress augmentation of limbic epileptogenesis: the role of corticosterone and HPA axis programming

AS Koe, MR Salzberg, MJ Morris, TJ O'Brien… - …, 2014 - Elsevier
Early life stress causes long-lasting effects on the limbic system that may be relevant to the
development of mesial temporal lobe epilepsy (MTLE) and its associated psychopathology …

Gastrodin reduces the severity of status epilepticus in the rat pilocarpine model of temporal lobe epilepsy by inhibiting Nav1. 6 sodium currents

H Shao, Y Yang, A Qi, P Hong, G Zhu, X Cao… - Neurochemical …, 2017 - Springer
Temporal lobe epilepsy (TLE) is one of the most refractory types of adult epilepsy, and
treatment options remain unsatisfactory. Gastrodin (GAS), a phenolic glucoside used in …

[HTML][HTML] Long term effects of peripubertal stress on the thalamic reticular nucleus of female and male mice

J Alcaide, Y Gramuntell, P Klimczak… - Neurobiology of …, 2024 - Elsevier
Adverse experiences during infancy and adolescence have an important and enduring
effect on the brain and are predisposing factors for mental disorders, particularly major …

Delta-frequency augmentation and synchronization in seizure discharges and telencephalic transmission

P Chou, GH Wang, SW Hsueh, YC Yang, CC Kuo - Iscience, 2020 - cell.com
Epileptic seizures constitute a common neurological disease primarily diagnosed by
characteristic rhythms or waves in the local field potentials (LFPs) of cerebral cortices or …

Influence of early-life stress on hippocampal synaptic and network properties

A Rozov, A Fedulina, V Krut', R Sokolov… - Frontiers in Neural …, 2024 - frontiersin.org
According to the World Health Organization, the number of people suffering from depressive
disorders worldwide is approaching 350 million. The consequences of depressive disorders …