Prostate cancer review: genetics, diagnosis, treatment options, and alternative approaches

M Sekhoacha, K Riet, P Motloung, L Gumenku… - Molecules, 2022 - mdpi.com
Simple Summary Prostate cancer affects men of all racial and ethnic groups and leads to
higher rates of mortality in those belonging to a lower socioeconomic status due to late …

Chemical design and synthesis of functionalized probes for imaging and treating tumor hypoxia

J Liu, W Bu, J Shi - Chemical reviews, 2017 - ACS Publications
Hypoxia development in tumor is closely associated with its increased aggressiveness and
strong resistance to therapy, leading to the poor prognosis in several cancer types …

The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities

C WalshJoseph, C KolbHartmuth - Antioxidants & redox signaling, 2014 - liebertpub.com
Tumor hypoxia is a well-established biological phenomenon that affects the curability of
solid tumors, regardless of treatment modality. Especially for head and neck cancer patients …

Imaging tumour hypoxia with oxygen-enhanced MRI and BOLD MRI

JPB O'Connor, SP Robinson… - The British journal of …, 2019 - academic.oup.com
Hypoxia is known to be a poor prognostic indicator for nearly all solid tumours and also is
predictive of treatment failure for radiotherapy, chemotherapy, surgery and targeted …

Targeting hypoxia in solid and haematological malignancies

B Harris, S Saleem, N Cook, E Searle - Journal of Experimental & Clinical …, 2022 - Springer
Tumour hypoxia is a known and extensively researched phenomenon that occurs in both
solid and haematological malignancies. As cancer cells proliferate, demand for oxygen can …

MRI-linear accelerator radiotherapy systems

GP Liney, B Whelan, B Oborn, M Barton, P Keall - Clinical Oncology, 2018 - Elsevier
The desire to utilise soft-tissue image guidance at the time of radiation treatment has led to
the development of several hybrid magnetic resonance imaging (MRI) linear accelerators …

Correlations of noninvasive BOLD and TOLD MRI with pO2 and relevance to tumor radiation response

RR Hallac, H Zhou, R Pidikiti, K Song… - Magnetic resonance …, 2014 - Wiley Online Library
Purpose To examine the potential use of blood oxygenation level dependent (BOLD) and
tissue oxygenation level dependent (TOLD) contrast MRI to assess tumor oxygenation and …

Hypoxia as a biomarker for radioresistant cancer stem cells

C Peitzsch, R Perrin, RP Hill… - International journal of …, 2014 - Taylor & Francis
Background: Tumor initiation, growth and relapse after therapy are thought to be driven by a
population of cells with stem cell characteristics, named cancer stem cells (CSC). The …

Combined MR imaging of oxygen consumption and supply reveals tumor hypoxia and aggressiveness in prostate cancer patients

T Hompland, KH Hole, HB Ragnum, EK Aarnes… - Cancer research, 2018 - AACR
The established role of hypoxia-induced signaling in prostate cancer growth, metastasis,
and response to treatment suggests that a method to image hypoxia in tumors could aid …

Imaging brain oxygenation with MRI using blood oxygenation approaches: methods, validation, and clinical applications

T Christen, DS Bolar… - American journal of …, 2013 - Am Soc Neuroradiology
In many pathophysiologic situations, including brain neoplasms, neurodegenerative
disease, and chronic and acute ischemia, an imbalance exists between oxygen tissue …