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Insulin resistance and neurodegeneration: progress towards the development of new therapeutics for Alzheimer's disease
SM De la Monte - Drugs, 2017 - Springer
Alzheimer's disease (AD) should be regarded as a degenerative metabolic disease caused
by brain insulin resistance and deficiency, and overlap** with the molecular, biochemical …
by brain insulin resistance and deficiency, and overlap** with the molecular, biochemical …
Brain metabolic dysfunction at the core of Alzheimer's disease
Growing evidence supports the concept that Alzheimer's disease (AD) is fundamentally a
metabolic disease with molecular and biochemical features that correspond with diabetes …
metabolic disease with molecular and biochemical features that correspond with diabetes …
Type 3 diabetes is sporadic Alzheimer׳ s disease: mini-review
SM de la Monte - European neuropsychopharmacology, 2014 - Elsevier
Alzheimer׳ s disease (AD) is the most common cause of dementia in North America.
Growing evidence supports the concept that AD is a metabolic disease mediated by …
Growing evidence supports the concept that AD is a metabolic disease mediated by …
Migraine triggers and oxidative stress: a narrative review and synthesis
Background Blau theorized that migraine triggers are exposures that in higher amounts
would damage the brain. The recent discovery that the TRPA1 ion channel transduces …
would damage the brain. The recent discovery that the TRPA1 ion channel transduces …
Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease
S M. de la Monte - Current Alzheimer Research, 2012 - benthamdirect.com
Alzheimer's disease [AD] is the most common cause of dementia in North America. Despite
30+ years of intense investigation, the field lacks consensus regarding the etiology and …
30+ years of intense investigation, the field lacks consensus regarding the etiology and …
Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress
Mitochondria are important for providing cellular energy ATP through the oxidative
phosphorylation pathway. They are also critical in regulating many cellular functions …
phosphorylation pathway. They are also critical in regulating many cellular functions …
Neurodegenerative Diseases: Might Citrus Flavonoids Play a Protective Role?
S Cirmi, N Ferlazzo, GE Lombardo… - Molecules, 2016 - mdpi.com
Neurodegenerative diseases (ND) result from the gradual and progressive degeneration of
the structure and function of the central nervous system or the peripheral nervous system or …
the structure and function of the central nervous system or the peripheral nervous system or …
Naringenin ameliorates Alzheimer's disease (AD)-type neurodegeneration with cognitive impairment (AD-TNDCI) caused by the intracerebroventricular-streptozotocin …
Oxidative stress is involved in Alzheimer's disease (AD)-type neurodegeneration with
cognitive impairment (AD-TNDCI) as well as age related cognitive deficit. The present study …
cognitive impairment (AD-TNDCI) as well as age related cognitive deficit. The present study …
Malignant brain aging: the formidable link between dysregulated signaling through mechanistic target of rapamycin pathways and alzheimer's disease (type 3 …
SM de la Monte - Journal of Alzheimer's Disease, 2023 - journals.sagepub.com
Malignant brain aging corresponds to accelerated age-related declines in brain functions
eventually derailing the self-sustaining forces that govern independent vitality. Malignant …
eventually derailing the self-sustaining forces that govern independent vitality. Malignant …
Nitrosamine exposure causes insulin resistance diseases: relevance to type 2 diabetes mellitus, non-alcoholic steatohepatitis, and Alzheimer's disease
The current epidemics of type 2 diabetes mellitus (T2DM), non-alcoholic steatohepatitis
(NASH), and Alzheimer's disease (AD) all represent insulin-resistance diseases. Previous …
(NASH), and Alzheimer's disease (AD) all represent insulin-resistance diseases. Previous …