▪ Abstract Toxic shock syndrome (TSS) is an acute onset illness characterized by fever, rash
formation, and hypotension that can lead to multiple organ failure and lethal shock, as well …

Staphylococcus aureus is an opportunistic pathogen and the leading cause of a wide range
of severe clinical infections. The range of diseases reflects the diversity of virulence factors …

Horizontal gene transfer (HGT) in bacteria and archaea occurs through phage transduction,
transformation, or conjugation, and the latter is particularly important for the spread of …

Antibiotics target conserved bacterial cellular pathways or growth functions and therefore
cannot selectively kill specific members of a complex microbial population. Here, we …

To enhance the research capabilities of investigators interested in Staphylococcus aureus,
the Nebraska Center for Staphylococcal Research (CSR) has generated a sequence …

Nosocomial infections that result in the formation of biofilms on the surfaces of biomedical
implants are a leading cause of sepsis and are often associated with colonization of the …

The production of most toxins and other exoproteins in Staphylococcus aureus is controlled
globally by a complex polycistronic regulatory locus, agr. Secretory proteins are up …

In many prokaryotes, type III clustered regularly interspaced short palindromic repeat
(CRISPR)–CRISPR-associated (Cas) systems detect and degrade invasive genetic …

All immune systems must distinguish self from non-self to repel invaders without inducing
autoimmunity. Clustered, regularly interspaced, short palindromic repeat (CRISPR) loci …

Clustered regularly interspaced short palindromic repeat (CRISPR) loci and their associated
(Cas) proteins provide adaptive immunity against viral infection in prokaryotes. Upon …