Comparative systematic review and meta-analysis of reactogenicity, immunogenicity and efficacy of vaccines against SARS-CoV-2
As SARS-CoV-2 vaccines are deployed worldwide, a comparative evaluation is important to
underpin decision-making. We here report a systematic literature review and meta-analysis …
underpin decision-making. We here report a systematic literature review and meta-analysis …
Viral vector platforms within the gene therapy landscape
Throughout its 40-year history, the field of gene therapy has been marked by many
transitions. It has seen great strides in combating human disease, has given hope to patients …
transitions. It has seen great strides in combating human disease, has given hope to patients …
[HTML][HTML] Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind …
Background Older adults (aged≥ 70 years) are at increased risk of severe disease and
death if they develop COVID-19 and are therefore a priority for immunisation should an …
death if they develop COVID-19 and are therefore a priority for immunisation should an …
[HTML][HTML] T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
Coronavirus Disease 2019 (COVID-19), has caused a global pandemic, and safe, effective …
Coronavirus Disease 2019 (COVID-19), has caused a global pandemic, and safe, effective …
Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial
Background The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) might be curtailed by vaccination. We assessed the safety, reactogenicity, and …
2) might be curtailed by vaccination. We assessed the safety, reactogenicity, and …
Next-generation influenza vaccines: opportunities and challenges
CJ Wei, MC Crank, J Shiver, BS Graham… - Nature reviews Drug …, 2020 - nature.com
Seasonal influenza vaccines lack efficacy against drifted or pandemic influenza strains.
Develo** improved vaccines that elicit broader immunity remains a public health priority …
Develo** improved vaccines that elicit broader immunity remains a public health priority …
[HTML][HTML] Safety and immunogenicity of a candidate Middle East respiratory syndrome coronavirus viral-vectored vaccine: a dose-escalation, open-label, non …
PM Folegatti, M Bittaye, A Flaxman… - The Lancet Infectious …, 2020 - thelancet.com
Summary Background Cases of Middle East respiratory syndrome coronavirus (MERS-CoV)
infection continue to rise in the Arabian Peninsula 7 years after it was first described in Saudi …
infection continue to rise in the Arabian Peninsula 7 years after it was first described in Saudi …
Assessment of a quadrivalent nucleoside-modified mRNA vaccine that protects against group 2 influenza viruses
M McMahon, G O'Dell, J Tan… - Proceedings of the …, 2022 - National Acad Sciences
Combined vaccine formulations targeting not only hemagglutinin but also other influenza
virus antigens could form the basis for a universal influenza virus vaccine that has the …
virus antigens could form the basis for a universal influenza virus vaccine that has the …
A multi-targeting, nucleoside-modified mRNA influenza virus vaccine provides broad protection in mice
Influenza viruses are respiratory pathogens of public health concern worldwide with up to
650,000 deaths occurring each year. Seasonal influenza virus vaccines are employed to …
650,000 deaths occurring each year. Seasonal influenza virus vaccines are employed to …
Adenovirus vector-based vaccine for infectious diseases
F Sakurai, M Tachibana, H Mizuguchi - Drug Metabolism and …, 2022 - Elsevier
Replication-incompetent adenovirus (Ad) vectors have been widely used as gene delivery
vehicles in both gene therapy studies and basic studies for gene function analysis due to …
vehicles in both gene therapy studies and basic studies for gene function analysis due to …