Some individuals with a particular disease-causing mutation or genotype fail to express
most if not all features of the disease in question, a phenomenon that is known as 'reduced …

Since the discovery of microRNAs (miRNAs), the study of these small noncoding RNAs has
steadily increased and more than 10,000 papers have already been published. The great …

Abstract miRNAs have emerged, in the last decade, as key players in the carcinogenic
process, with many candidates identified as playing important roles in many aspects of …

Introduction• Classification of miRNA‐related SNPs‐SNPs in miRNA processing machinery‐
SNPs in pri‐, pre‐, mat‐miRNAs‐SNPs in miRNA‐binding sites• MiRNA‐related SNPs and …

Breast cancer is a complex and heterogeneous disease. Signaling by estrogen receptor
(ER), progesterone receptor (PR), and/or human EGF-like receptor 2 (HER2) is a main driver …

The last decade has seen tremendous improvements in the understanding of human
variations and their association with human traits and diseases. The availability of high …

Abstract Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by Adenosine DeAminases
acting on double-stranded RNA (dsRNA)(ADAR), occurs predominantly in the 3 …

Background MicroRNAs regulate gene expression at the post-transcriptional level and
involved in diverse biological and pathological processes, including tumorigenesis …

Dihydropyrimidine dehydrogenase (DPD, encoded by DPYD) is the rate-limiting enzyme in
the uracil catabolic pathway and has a pivotal role in the pharmacokinetics of the commonly …

Background MicroRNAs (miRNAs) are a novel class of endogenous, non-coding, single-
stranded RNAs capable of regulating gene expression by suppressing translation or …