Single-cell sequencing of brain cell transcriptomes and epigenomes
Single-cell sequencing technologies, including transcriptomic and epigenomic assays, are
transforming our understanding of the cellular building blocks of neural circuits. By directly …
transforming our understanding of the cellular building blocks of neural circuits. By directly …
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays
Spatially resolved transcriptomic technologies are promising tools to study complex
biological processes such as mammalian embryogenesis. However, the imbalance between …
biological processes such as mammalian embryogenesis. However, the imbalance between …
A multimodal cell census and atlas of the mammalian primary motor cortex
Principal manuscript editors, Analysis coordination… - Nature, 2021 - nature.com
Here we report the generation of a multimodal cell census and atlas of the mammalian
primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network …
primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network …
[HTML][HTML] A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation
The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles in
perception, cognition, emotion, and learning. We profiled∼ 1.3 million cells covering the …
perception, cognition, emotion, and learning. We profiled∼ 1.3 million cells covering the …
Deep learning and alignment of spatially resolved single-cell transcriptomes with Tangram
Charting an organs' biological atlas requires us to spatially resolve the entire single-cell
transcriptome, and to relate such cellular features to the anatomical scale. Single-cell and …
transcriptome, and to relate such cellular features to the anatomical scale. Single-cell and …
[HTML][HTML] Phenotypic variation of transcriptomic cell types in mouse motor cortex
Cortical neurons exhibit extreme diversity in gene expression as well as in morphological
and electrophysiological properties 1, 2. Most existing neural taxonomies are based on …
and electrophysiological properties 1, 2. Most existing neural taxonomies are based on …
[HTML][HTML] Cellular anatomy of the mouse primary motor cortex
An essential step toward understanding brain function is to establish a structural framework
with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and …
with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and …
DNA methylation atlas of the mouse brain at single-cell resolution
Mammalian brain cells show remarkable diversity in gene expression, anatomy and
function, yet the regulatory DNA landscape underlying this extensive heterogeneity is poorly …
function, yet the regulatory DNA landscape underlying this extensive heterogeneity is poorly …
gEAR: Gene Expression Analysis Resource portal for community-driven, multi-omic data exploration
To the Editor—Biologists are important stakeholders in genomic data, both as data
generators and as users of genomic data resources. Tools to efficiently visualize and …
generators and as users of genomic data resources. Tools to efficiently visualize and …
GluN3A NMDA receptor subunits: more enigmatic than ever?
O Crawley, MJ Conde‐Dusman… - The Journal of …, 2022 - Wiley Online Library
Non‐conventional N‐methyl‐d‐aspartate receptors (NMDARs) containing GluN3A subunits
have unique biophysical, signalling and localization properties within the NMDAR family …
have unique biophysical, signalling and localization properties within the NMDAR family …