Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Inflammation is increasingly recognized as being of both physiological and pathological
importance in the immature brain. The rationale of this review is to present an update on this …

More than 95 percent of infants who have neonatal stroke survive to adulthood, and many
have residual motor or cognitive disabilities. This article makes the point that recognition of …

Perinatal hypoxic‐ischemic encephalopathy (HIE) is a significant cause of mortality and
morbidity in infants and young children. Therapeutic opportunities are very limited for …

Knowledge of the nature, prognosis, and ways to treat brain lesions in neonatal infants has
increased remarkably. Neonatal hypoxic-ischaemic encephalopathy (HIE) in term infants …

Perinatal insults such as hypoxia–ischemia induces secondary brain injury. In order to
develop the next generation of neuroprotective therapies, we urgently need to understand …

Acute post-asphyxial encephalopathy occurring around the time of birth remains a major
cause of death and disability. The recent seminal insight that allows active neuroprotective …

The possibility that hypothermia during or after resuscitation from asphyxia at birth, or
cardiac arrest in adults, might reduce evolving damage has tantalized clinicians for a very …

Necrostatin-1 inhibits receptor-interacting protein (RIP)-1 kinase and programmed necrosis
and is neuroprotective in adult rodent models. Owing to the prominence of necrosis and …

This series of Reviews on cell death explores the creation of new therapies for correcting
excessive or deficient cell death in human disease. Signal transduction pathways controlling …