The translation initiation step in eukaryotes is highly regulated and rate-limiting. During this
process, the 40S ribosomal subunit is usually recruited to the 5′ terminus of the mRNA. It …

The original purification of the heterotrimeric eIF4F was published over 30 years ago (Grifo,
JA, Tahara, SM, Morgan, MA, Shatkin, AJ, and Merrick, WC (1983) J. Biol. Chem. 258, 5804 …

Translation initiation factors eIF4A and eIF4G form, together with the cap-binding factor
eIF4E, the eIF4F complex, which is crucial for recruiting the small ribosomal subunit to the …

Summary The RNA helicase eIF4A plays a key role in unwinding of mRNA and scanning
during translation initiation. Free eIF4A is a poor helicase and requires the accessory …

DEAD-box helicases catalyze the ATP-dependent unwinding of RNA duplexes. They share
a helicase core formed by two RecA-like domains that carries a set of conserved motifs …

Programmed Cell Death 4 (PDCD4) is a protein known to bind eukaryotic initiation factor 4A
(eIF4A), inhibit translation initiation, and act as a tumor suppressor. PDCD4 contains two C …

DEAD box proteins catalyze the ATP-dependent unwinding of double-stranded RNA
(dsRNA). In addition, they facilitate protein displacement and remodeling of RNA or …

Initiation is a highly regulated rate-limiting step of mRNA translation. During cap-dependent
translation, the cap-binding protein eIF4E recruits the mRNA to the ribosome. Specific …

Protein translation is a critical regulatory event involved in nearly all physiological and
pathological processes. Eukaryotic translation initiation factors are dedicated to translation …

Protein synthesis is a fundamental biological mechanism bringing the DNA-encoded genetic
information into life by its translation into molecular effectors-proteins. The initiation phase of …