Visually sensitive seizures: An updated review by the Epilepsy Foundation

RS Fisher, JN Acharya, FM Baumer, JA French… - …, 2022 - Wiley Online Library
Light flashes, patterns, or color changes can provoke seizures in up to 1 in 4000 persons.
Prevalence may be higher because of selection bias. The Epilepsy Foundation reviewed …

Progress report on new antiepileptic drugs: a summary of the Eigth Eilat Conference (EILAT VIII)

M Bialer, SI Johannessen, HJ Kupferberg, RH Levy… - Epilepsy research, 2007 - Elsevier
The Eigth Eilat Conference on New Antiepileptic Drugs (AEDs)-EILAT VII, took place in
Sitges, Barcelona from the 10th to 14th September, 2006. Basic scientists, clinical …

Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: relationship to anti-convulsant properties

M Gillard, B Fuks, K Leclercq, A Matagne - European journal of …, 2011 - Elsevier
Brivaracetam is a novel synaptic vesicle protein 2A (SV2A) ligand reported to be 10 fold
more potent than levetiracetam in animal models of epilepsy. This study reports the binding …

Levetiracetam and brivaracetam: a review of evidence from clinical trials and clinical experience

BJ Steinhoff, AM Staack - Therapeutic advances in …, 2019 - journals.sagepub.com
Until the early 1990s, a limited number of antiepileptic drugs (AEDs) were available. Since
then, a large variety of new AEDs have been developed and introduced, several of them …

Non-invasive EEG evaluation in epilepsy diagnosis

F Rosenow, KM Klein, HM Hamer - Expert review of …, 2015 - Taylor & Francis
The EEG is an invaluable tool in the diagnosis of epilepsy which guides clinical
management. It helps to determine if attacks are of epileptic origin, allows the estimation of …

[HTML][HTML] Efficacy, tolerability and safety of add-on third-generation antiseizure medications in treating focal seizures worldwide: A network meta-analysis of randomised …

Y Chen, W Li, C Lu, X Gao, H Song, Y Zhang… - …, 2024 - thelancet.com
Background Adjunctive newer antiseizure medications (ASMs) are being used in patients
with treatment-resistant focal-onset seizures (FOS). An updated network meta-analysis …

Efficacy and tolerability of adjunctive brivaracetam in adults with uncontrolled partial‐onset seizures: a phase IIb, randomized, controlled trial

W Van Paesschen, E Hirsch, M Johnson, U Falter… - …, 2013 - Wiley Online Library
Purpose: To evaluate the efficacy and tolerability of adjunctive brivaracetam (BRV), a novel
high‐affinity synaptic vesicle protein 2A ligand that also displays inhibitory activity at …

Adjunctive brivaracetam for refractory partial-onset seizures: a randomized, controlled trial

JA French, C Costantini, A Brodsky, P von Rosenstiel - Neurology, 2010 - neurology.org
Objective: To explore efficacy and safety/tolerability of adjunctive brivaracetam (BRV), a
novel, high-affinity synaptic vesicle protein 2A ligand, which also inhibits neuronal voltage …

Current state of the epilepsy drug and device pipeline

SW Terman, L Kirkpatrick, LF Akiyama, W Baajour… - …, 2024 - Wiley Online Library
The field of epilepsy has undergone substantial advances as we develop novel drugs and
devices. Yet considerable challenges remain in develo** broadly effective, well‐tolerated …

A review of the pharmacology and clinical efficacy of brivaracetam

P Klein, A Diaz, T Gasalla… - … advances and applications, 2018 - Taylor & Francis
Brivaracetam (BRV; Briviact) is a new antiepileptic drug (AED) approved for adjunctive
treatment of focal (partial-onset) seizures in adults. BRV is a selective, high-affinity ligand for …