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Unlocking the promise of mRNA therapeutics
E Rohner, R Yang, KS Foo, A Goedel… - Nature biotechnology, 2022 - nature.com
The extraordinary success of mRNA vaccines against coronavirus disease 2019 (COVID-19)
has renewed interest in mRNA as a means of delivering therapeutic proteins. Early clinical …
has renewed interest in mRNA as a means of delivering therapeutic proteins. Early clinical …
Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading
J Rädler, D Gupta, A Zickler, SEL Andaloussi - Molecular Therapy, 2023 - cell.com
Extracellular vesicles (EVs) are gaining increasing attention for diagnostic and therapeutic
applications in various diseases. These natural nanoparticles benefit from favorable safety …
applications in various diseases. These natural nanoparticles benefit from favorable safety …
Identification of storage conditions stabilizing extracellular vesicles preparations
Extracellular vesicles (EVs) play a key role in many physiological and pathophysiological
processes and hold great potential for therapeutic and diagnostic use. Despite significant …
processes and hold great potential for therapeutic and diagnostic use. Despite significant …
CD63 sorts cholesterol into endosomes for storage and distribution via exosomes
Extracellular vesicles such as exosomes are now recognized as key players in intercellular
communication. Their role is influenced by the specific repertoires of proteins and lipids …
communication. Their role is influenced by the specific repertoires of proteins and lipids …
Antibody-displaying extracellular vesicles for targeted cancer therapy
Extracellular vesicles (EVs) function as natural delivery vectors and mediators of biological
signals across tissues. Here, by leveraging these functionalities, we show that EVs …
signals across tissues. Here, by leveraging these functionalities, we show that EVs …
Targeted therapy using engineered extracellular vesicles: principles and strategies for membrane modification
Q Liu, D Li, X Pan, Y Liang - Journal of Nanobiotechnology, 2023 - Springer
Abstract Extracellular vesicles (EVs) are 30–150 nm membrane-bound vesicles naturally
secreted by cells and play important roles in intercellular communication by delivering …
secreted by cells and play important roles in intercellular communication by delivering …
The cellular response to extracellular vesicles is dependent on their cell source and dose
Extracellular vesicles (EVs) have been established to play important roles in cell-cell
communication and shown promise as therapeutic agents. However, we still lack a basic …
communication and shown promise as therapeutic agents. However, we still lack a basic …
Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles
Extracellular vesicles (EVs) are gaining ground as next-generation drug delivery modalities.
Genetic fusion of the protein of interest to a scaffold protein with high EV-sorting ability …
Genetic fusion of the protein of interest to a scaffold protein with high EV-sorting ability …
Cell-derived extracellular vesicles for CRISPR/Cas9 delivery: engineering strategies for cargo packaging and loading
Y Liang, Z Iqbal, J Wang, L Xu, X Xu, K Ouyang… - Biomaterials …, 2022 - pubs.rsc.org
Genome editing technology has emerged as a potential therapeutic tool for treating
incurable diseases. In particular, the discovery of clustered regularly interspaced short …
incurable diseases. In particular, the discovery of clustered regularly interspaced short …
Exploring the clinical transition of engineered exosomes designed for intracellular delivery of therapeutic proteins
Extracellular vesicles, particularly exosomes, have emerged as promising drug delivery
systems owing to their unique advantages, such as biocompatibility, immune tolerability, and …
systems owing to their unique advantages, such as biocompatibility, immune tolerability, and …