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Distribution of silent cerebral infarcts in adults with sickle cell disease
Background and Objectives Previously we demonstrated that 90% of infarcts in children with
sickle cell anemia occur in the border zone regions of cerebral blood flow (CBF). We tested …
sickle cell anemia occur in the border zone regions of cerebral blood flow (CBF). We tested …
Cerebral hemodynamic changes after haploidentical hematopoietic stem cell transplant in adults with sickle cell disease
Preliminary evidence from a series of 4 adults with sickle cell disease (SCD) suggests that
hematopoietic stem cell transplant (HSCT) improves cerebral hemodynamics. HSCT largely …
hematopoietic stem cell transplant (HSCT) improves cerebral hemodynamics. HSCT largely …
Cerebral hemodynamics and oxygenation in adult patients with sickle cell disease after stem cell transplantation
Sickle cell disease (SCD) is characterized by chronic hemolytic anemia associated with
impaired cerebral hemodynamics and oxygen metabolism. Hematopoietic stem cell …
impaired cerebral hemodynamics and oxygen metabolism. Hematopoietic stem cell …
Cerebral vascular shunting and oxygen metabolism in sickle cell disease
Patients with sickle cell disease (SCD) are at elevated risk of silent cerebral infarcts and
strokes; however, they frequently lack established stroke risk factors (eg, macrovascular …
strokes; however, they frequently lack established stroke risk factors (eg, macrovascular …
Effect of voxelotor on cerebral perfusion and cerebral oxygen metabolism and cardiac stress in adult patients with sickle cell disease
K Konté, L Afzali‐Hashemi, KPA Baas… - American Journal of …, 2025 - Wiley Online Library
Sickle cell disease (SCD) is complicated by silent cerebral infarcts (SCIs), for which anemia
is an important risk factor. Despite normal oxygen delivery (OD), cerebral vascular reserve …
is an important risk factor. Despite normal oxygen delivery (OD), cerebral vascular reserve …
Venous Blood Oxygenation Measurements Using TRUST and T2‐TRIR MRI During Hypoxic and Hypercapnic Gas Challenges
Background Oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen
(CMRO2) may serve as biomarkers in several diseases. OEF and CMRO2 can be estimated …
(CMRO2) may serve as biomarkers in several diseases. OEF and CMRO2 can be estimated …
Cerebral hemodynamics and oxygen metabolism in patients with milder and severe forms of sickle cell disease and thalassemia
Silent cerebral infarcts (SCIs) are present in patients with sickle cell disease (SCD) and
thalassemia, but the pathophysiology of SCIs is not fully understood. Previous studies …
thalassemia, but the pathophysiology of SCIs is not fully understood. Previous studies …