G-quadruplexes and their regulatory roles in biology
D Rhodes, HJ Lipps - Nucleic acids research, 2015 - academic.oup.com
Abstract 'If G-quadruplexes form so readily in vitro, Nature will have found a way of using
them in vivo'(Statement by Aaron Klug over 30 years ago). During the last decade, four …
them in vivo'(Statement by Aaron Klug over 30 years ago). During the last decade, four …
DNA secondary structures: stability and function of G-quadruplex structures
In addition to the canonical double helix, DNA can fold into various other inter-and
intramolecular secondary structures. Although many such structures were long thought to be …
intramolecular secondary structures. Although many such structures were long thought to be …
Metal cations in G-quadruplex folding and stability
This review is focused on the structural and physicochemical aspects of metal cation
coordination to G-Quadruplexes (GQ) and their effects on GQ stability and conformation. G …
coordination to G-Quadruplexes (GQ) and their effects on GQ stability and conformation. G …
Quadruplex nucleic acids as novel therapeutic targets
S Neidle - Journal of medicinal chemistry, 2016 - ACS Publications
Quadruplex-forming sequences are widely prevalent in human and other genomes,
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …
RNA G-quadruplexes in biology: principles and molecular mechanisms
Abstract G-quadruplexes (G4s) are extremely stable DNA or RNA secondary structures
formed by sequences rich in guanine. These structures are implicated in many essential …
formed by sequences rich in guanine. These structures are implicated in many essential …
Small-molecule–induced DNA damage identifies alternative DNA structures in human genes
Guanine-rich DNA sequences that can adopt non–Watson-Crick structures in vitro are
prevalent in the human genome. Whether such structures normally exist in mammalian cells …
prevalent in the human genome. Whether such structures normally exist in mammalian cells …
Thioflavin T as an efficient inducer and selective fluorescent sensor for the human telomeric G-quadruplex DNA
The quest for a G-quadruplex specific fluorescent sensor among other DNA forms under
physiological salt conditions has been addressed in this article. We demonstrate for the first …
physiological salt conditions has been addressed in this article. We demonstrate for the first …
G-quadruplex structures: in vivo evidence and function
HJ Lipps, D Rhodes - Trends in cell biology, 2009 - cell.com
Although many biochemical and structural studies have demonstrated that DNA sequences
containing runs of adjacent guanines spontaneously fold into G-quadruplex DNA structures …
containing runs of adjacent guanines spontaneously fold into G-quadruplex DNA structures …
Recent progress of targeted G-quadruplex-preferred ligands toward cancer therapy
A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-
rich sequences, and has profound implications for various pharmacological and biological …
rich sequences, and has profound implications for various pharmacological and biological …
5′-UTR RNA G-quadruplexes: translation regulation and targeting
RNA structures in the untranslated regions (UTRs) of mRNAs influence post-transcriptional
regulation of gene expression. Much of the knowledge in this area depends on canonical …
regulation of gene expression. Much of the knowledge in this area depends on canonical …