Context-specific determinants of the immunosuppressive tumor microenvironment in pancreatic cancer

C Falcomatà, S Bärthel, G Schneider, R Rad… - Cancer …, 2023 - aacrjournals.org
Immunotherapies have shown benefits across a range of human cancers, but not pancreatic
ductal adenocarcinoma (PDAC). Recent evidence suggests that the immunosuppressive …

Targeting the tumour vasculature: from vessel destruction to promotion

S Guelfi, K Hodivala-Dilke, G Bergers - Nature Reviews Cancer, 2024 - nature.com
As angiogenesis was recognized as a core hallmark of cancer growth and survival, several
strategies have been implemented to target the tumour vasculature. Yet to date, attempts …

The interplay between extracellular matrix remodeling and cancer therapeutics

J Prakash, Y Shaked - Cancer discovery, 2024 - aacrjournals.org
The extracellular matrix (ECM) is an abundant noncellular component of most solid tumors
known to support tumor progression and metastasis. The interplay between the ECM and …

Mechanoregulation of YAP and TAZ in cellular homeostasis and disease progression

X Cai, KC Wang, Z Meng - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Biophysical cues, such as mechanical properties, play a critical role in tissue growth and
homeostasis. During organ development and tissue injury repair, compressive and tensional …

In vivo assembly enhanced binding effect augments tumor specific ferroptosis therapy

DY Hou, DB Cheng, NY Zhang, ZJ Wang, XJ Hu… - Nature …, 2024 - nature.com
Emerging evidence indicates that the activation of ferroptosis by glutathione peroxidase 4
(GPX4) inhibitors may be a prominent therapeutic strategy for tumor suppression. However …